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Genomic Medicine XVI: Host Genomics and Infectious Disease

Event Details

On December 12-13, 2024, the National Human Genome Research Institute (NHGRI) and the National Institute of Allergy and Infectious Diseases (NIAID) will co-sponsor the 16th Genomic Medicine meeting, Host Genomics and Infectious Disease: Opportunities for Implementing Genomic Medicine, in Bethesda MD.

The meeting aims to identify needs, opportunities, and challenges for applying a patient’s genomic information (genome sequence, transcriptomic, epigenomic, etc. data) in the diagnosis, prevention, and treatment of infectious diseases. Persistent barriers and evidence gaps will be examined as opportunities for additional research.

Registration Form (deadline Oct 25)

Housing Form (deadline Nov 20)

Request an Accommodation

Meeting Objectives

Browse Agenda by Day: December 12 | December 13

All times are in ET.

to

Hybrid: Zoom Webinar (Requires Registration) and In-Person
The Bethesdan Hotel

8210 Wisconsin Ave
Bethesda, MD 20814

Webcast Viewing Platforms

Zoom Webinar (Requires Registration)

GenomeTV Live

Vimeo

YouTube

Meeting Objectives

The objectives of the meeting are to:

  • Define currently available approaches for using host genomic information in the diagnosis, prevention, and treatment of infectious diseases
  • Examine obstacles and potential solutions to incorporating these and on-the-horizon approaches in clinical care (e.g., cost, reimbursement, regulatory, access, education, insufficient guidelines, and sparse ascertainment of underrepresented groups)
  • Identify research opportunities for increasing implementation of host genomic information in clinical care of infectious diseases

December 12

8:30 a.m. - Breakfast

9:00 a.m. - Welcome and Introductions

Goals of Genomic Medicine XVI
Eric Green
Jeane Marrazzo

Structure, Goals, and Products of Prior NHGRI Genomic Medicine Meetings
Teri Manolio

9:15 a.m. - Session 1: Laying the Groundwork
Moderators: Eric Green, Jeane Marrazzo

Keynote 1: Inherited disorders of immunity
Jennifer Puck, UCSF

Keynote 2: Variant Pathogenicity in Rare Diseases within the ACMG and ClinGen Framework
Ivan Chinn, Baylor

Discussion

10:45 a.m. - Break

11:05 a.m. - Session 2: “Pathogen-First,” “Phenotype-First,” and “Sequence-First” Approaches to Genomic Medicine Implementation in Infectious Diseases 
Moderators: Jonathan Berg, Lucas Buyon

“Red flag” Infections suggesting genetically driven immunodeficiency
Dusan Bogunovic, Columbia

Primary Immune Disorders and Specialized Infectious Testing
Scott Canna, CHOP

NICU/PICU sequencing and variants predisposing to sepsis
Stephen Kingsmore, Rady

Discussion

12:35 p.m. - Lunch

1:20 p.m. - Session 3: Viral infections and Host Genomics
Moderators: Gail Jarvik, Casey Overby Taylor

Tales from the genomes: inherited disorders of immunity and human papillomaviruses oncogenesis.
Andrea Lisco, NIAID

CCR5 and host response to W Nile and other flavivirus infections
Jean Lim, Mount Sinai

Control of chronic infections like HBV, HCV
Priya Duggal, Johns Hopkins

IFNAR1, Viruses, and Pacific Public Health
Ryan Minster, University of Pittsburgh

Discussion

3:05 p.m. - Break

3:25 p.m. - Session 4: Current Status of Clinical Use of Host Genomic Information
Moderators: George Mensah, Inka Sastalla

The Evolving Landscape of Diagnostic Immunology: Past, Present, and Future
Roshini Abraham, Ohio State

Available technologies for assessing host response
Ephraim Tsalik, Danaher and Duke

Genomic diagnostics in sepsis/severe infection
Purvesh Khatri, Inflammatix and Stanford

Genetic counseling and inherited disorders of immunity
Morgan Similuk, NIAID

Discussion

5:10 p.m. - Adjourn Day 1

December 13

8:00 a.m. - Breakfast

8:30 a.m. - Welcome

8:40 a.m. - Session 5: Pharmacogenetics (PGx) and Infectious Disease Management
Moderators: Carol Bult, Dan Roden

Aminoglycosides and other ototoxic drugs, MT-RNR1 and other PGx variants, and hearing loss
Peter Steyger, Creighton

From Theory to Practice: Navigating Strategies and Barriers in the Clinical Implementation of Voriconazole Pharmacogenetics
Aniwaa Owusu Obeng, Mount Sinai

G6PD and sulfa, implementation, education, EHR
Roseann Donnelly, Massachusetts College of Pharmacy and Health Sciences

PGx and antiviral agents
David Haas, VUMC

Discussion

10:25 a.m. - Break

10:45 a.m. - Session 6: Implementation of Host Genomics in Clinical Care of Infectious Diseases
Moderators: Gillian Hooker, Erin Ramos

NIAID genome sequencing effort in the NIH Clinical Center
Magdalena Walkiewicz, NIAID

Challenges of lab medicine implementation of genomics
Sergio Rosenzweig, NIH

Integrating host and pathogen genomic data into EHR
Alex Baras, Johns Hopkins

Educating clinicians in host genomics and infectious diseases
Bob Nussbaum, UCSF

Discussion

12:30.m. - Break to grab lunches

1:00 p.m. - Research Directions for 3 Themes - Summary of Discussions
Moderators: Rex Chisholm, Steve Holland

Host genomic testing for diagnosis and management
Dusan Bogunovich, Columbia

Policy development and reimbursement strategies
Gillian Hooker, Concert Genetics

Technology development and application
Marc Williams, Geisinger

Discussion

2:00 p.m. - Summary and Next Steps
Geoff Ginsburg, Steve Holland, Teri Manolio

2:30 p.m. - Adjourn Day 2

Request an Accommodation

Sign language interpreting and CART services are available upon request to participate in this event. Individuals needing either of these services and/or other reasonable accommodations should contact Britny Kish at britny.kish@nih.gov, 240-381-1283. Requests should be made at least five days in advance. To access Telecommunications Relay Services (TRS), call 711. 

Last updated: October 22, 2024