Genomic Medicine XVI: Host Genomics and Infectious Disease

8:30 a.m. - Breakfast

9:00 a.m. - Welcome and Introductions

Goals of Genomic Medicine XVI

9:00 - 9:10
Eric Green
Jeanne Marrazzo

Structure, Goals, and Products of Prior NHGRI Genomic Medicine Meetings

9:10 - 9:15
Teri Manolio

9:15 a.m. - Session 1: Laying the Groundwork
Moderators: Eric Green, Jeanne Marrazzo

Keynote 1: Inherited Disorders of Immunity

9:15 - 9:35 a.m.
Jennifer Puck, UCSF

Keynote 2: Variant Pathogenicity in Rare Diseases within the ACMG and ClinGen Framework

9:35 - 9:55 a.m.
Ivan Chinn, Baylor

Discussion

9:55 - 10:45 a.m.

10:45 a.m. - Break

11:05 a.m. - Session 2: “Pathogen-First,” “Phenotype-First,” and “Sequence-First” Approaches to Genomic Medicine Implementation in Infectious Diseases 
Moderators: Jonathan Berg, Lucas Buyon

Rare Infections - Disease Penetrance and Host Genetic Architecture

11:05 - 11:20 a.m.
Dusan Bogunovic, Columbia

Primary Immune Disorders and Specialized Infectious Testing

11:20 - 11:35 a.m.
Scott Canna, CHOP

NICU/PICU Sequencing and Variants Predisposing to Sepsis

11:35 - 11:50 a.m.
Stephen Kingsmore, Rady

Discussion

11:50 a.m. - 12:35 p.m. 

12:35 p.m. - Lunch

1:20 p.m. - Session 3: Viral infections and Host Genomics
Moderators: Gail Jarvik, Casey Overby Taylor

Tales From the Genomes: Inherited Disorders of Immunity and Human Papillomaviruses Oncogenesis

1:20 - 1:35 p.m.
Andrea Lisco, NIAID

CCR5 and Host Response to West Nile and Other Flavivirus Infections

1:35 - 1:50 p.m.
Jean Lim, Mount Sinai

Understanding Viral Infection Through Host Genetics: Chronic Hepatitis B and C

1:50 - 2:05 p.m. 
Priya Duggal, Johns Hopkins

IFNAR1, Viruses, and Pacific Public Health

2:05 - 2:20 p.m.
Ryan Minster, University of Pittsburgh

Discussion

2:20 - 3:05 p.m.

3:05 p.m. - Break

3:25 p.m. - Session 4: Current Status of Clinical Use of Host Genomic Information
Moderators: George Mensah, Inka Sastalla

The Evolving Landscape of Diagnostic Immunology: Past, Present, and Future

3:25 - 3:40 p.m.
Roshini Abraham, Ohio State (Virtual)

Available Technologies for Assessing Host Response

3:40 - 3:55 p.m.
Ephraim Tsalik, Danaher and Duke

Translating Host Response-Based Diagnostics to Clinical Practice

3:55 - 4:10 p.m.
Purvesh Khatri, Inflammatix and Stanford

Bridging the Gap: Addressing Obstacles in Genetic Counseling for Immune Disorders

4:10 - 4:25 p.m.
Morgan Similuk, NIAID

Discussion

4:25 - 5:10 p.m.

5:10 p.m. - Adjourn Day 1

8:00 a.m. - Breakfast

8:30 a.m. - Welcome / Recap of Day 1
Geoffrey Ginsburg

8:40 a.m. - Session 5: Pharmacogenetics (PGx) and Infectious Disease Management
Moderators: Carol Bult, Dan Roden (Virtual)

Aminoglycosides, Clinical Settings and PGx Variants Mediate Drug-Induced Hearing Loss

8:40 - 8:55 a.m.
Peter Steyger, Creighton

From Theory to Practice: Navigating Strategies and Barriers in the Clinical Implementation of Voriconazole Pharmacogenetics

8:55 - 9:10 a.m.
Aniwaa Owusu Obeng, Mount Sinai

Unique Challenges with Implementing G6PD Genetic Testing to Prevent Drug-Induced Hemolytic Anemia

9:10 - 9:25 a.m.
Roseann Donnelly, Massachusetts College of Pharmacy and Health Sciences

Pharmacogenetics of Antiviral Agents

9:25 - 9:40 a.m.
David Haas, VUMC

Discussion

9:40 - 10:25 a.m.

10:25 a.m. - Break

10:45 a.m. - Session 6: Implementation of Host Genomics in Clinical Care of Infectious Diseases
Moderators: Gillian Hooker, Erin Ramos (Virtual)

From Data to Diagnosis: The Clinical Implementation of Genomic Insights

10:45 - 11:00 a.m.
Magdalena Walkiewicz, NIAID

Germline vs. Somatic Variants and Other Considerations in Clinical NGS Testing

11:00 - 11:15 a.m.
Katherine Calvo, NIH

Incorporating Pathogen Genomic Data Into the Electronic Health Record

11:15 - 11:30 a.m.
Matthew Robinson, Johns Hopkins

What Motivates Clinicians To Use Molecular Diagnostics and What Obstacles Are Encountered That Deter Them? A Personal View

11:30 - 11:45 a.m.
Robert Nussbaum, UCSF

Discussion

11:45 a.m. - 12:30 p.m.

12:30.m. - Break to grab lunches

1:00 p.m. - Research Directions for 3 Themes - Summary of Discussions
Moderators: Rex Chisholm, Steve Holland

Host Genomic Testing for Diagnosis and Management

1:00 - 1:15 p.m.
Dusan Bogunovic, Columbia

A Path to Sustainability: Policy Development & Reimbursement Strategies

1:15 - 1:30 p.m.
Gillian Hooker, Concert Genetics

Technology Development and Application

1:30 - 1:45 p.m.
Marc Williams, Geisinger

Discussion

1:45 - 2:00 p.m.

2:00 p.m. - Summary and Next Steps
Geoff Ginsburg, Steve Holland, Teri Manolio

2:30 p.m. - Adjourn Day 2