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News Release

The African Diaspora: History, Adaptation and Health

NIH Center for Research on Genomics and Global Health is participating in the H3Africa Consortium's effort to develop an African-specific genotyping array.

… … Researchers have made a good start in identifying and understanding genetic mutations that have evolved over thousands of years to protect Africans from disease-causing pathogens. Today, these same …

Educational Resources

Frameshift Mutation

A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three.

… number of deleted base pairs is not divisible by three. … Genetic Mutation, Base Pairs, DNA Sequence … A frameshift … in the addition of the wrong amino acids to the protein and/or the creation of a codon that stops the protein from …

Educational Resources

Nonsense Mutation

A nonsense mutation is the substitution of a single base pair that leads to the appearance of a stop codon where previously there was a codon specifying an amino acid.

… acid. … Nonsense Mutation, Missense Mutation, Base Pair, Genetic Code, Genetic Mutation … A nonsense mutation occurs in DNA when a …

News Release

NHGRI researcher calls for more genomic research of Africans, people of the African diaspora

More research must be done to understand the interactions of ancient genes with modern environments.

Educational Resources

Mutation

A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to ionizing radiation, exposure to chemicals called mutagens, or infection by viruses.

… Mutation … A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during … A mutation is a change in the DNA sequence of an organism. Mutations can result from errors in DNA replication during … a viral infection. Germline mutations (that occur in eggs and sperm) can be passed on to offspring, while somatic …

Educational Resources

Point Mutation

A point mutation is when a single base pair is altered.

… base pair is added, deleted or changed. While most point mutations are benign, they can also have various functional …

Educational Resources

Missense Mutation

A missense mutation is when the change of a single base pair causes the substitution of a different amino acid in the resulting protein.

… position in the resulting protein. Some missense mutations alter the function of the resulting protein. … A …

News Release

Study identifies African-specific genomic variant associated with obesity

Researchers have conducted the first study to look at the genomic underpinnings of obesity in continental Africans and African Americans.

… at the genomic underpinnings of obesity in continental Africans and African Americans. They discovered that approximately 1 … technology to understand, diagnose and treat genomic and genetic diseases. Additional information about NHGRI can be …

News Release

Findings: Induced pluripotent stem cells don't increase genetic mutations

A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.

… since Japanese researchers Shinya Yamanaka, M.D., Ph.D., and his graduate student Kazutoshi Takahashi, Ph.D., … that these cells are prone to increased numbers of genetic mutations. A new study by scientists at the National Human …

News Release

Forging a genomics research path across Africa

NIH-backed African scientists are engaged in a global research endeavor to understand the genetic basis of disease in all populations.

… engaged in a global research endeavor to understand the genetic basis of disease in all populations. But this can … have shown that African populations contain the oldest and most diverse set of human genes. However, most studies of … 2010, the National Institutes of Health (NIH) Common Fund and the United Kingdom's Wellcome Trust, in partnership with …