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News Release
Genomic analyses turned up genes that belong to inflammatory pathways.
… might be a common drug known as a tumor necrosis factor (TNF) inhibitor, prescribed worldwide to treat inflammatory … did blood work, x-rays and bone scans and put him on a TNF inhibitor to see if it could be used for to treat his …
News Release
NHGRI researchers have identified a genomic signature for some aggressive prostate tumors, which may help healthcare providers pinpoint treatment options.
… patients - and prostate tumors - might respond to PARP inhibitor therapy. The research team is now exploring the … the molecular signature predicts positive response to PARP inhibitor treatment better than currently available tools. …
News Release
NIH researchers have discovered a rare and sometimes lethal inflammatory disease - otulipenia - that primarily affects young children.
… had been treated with anti-tumor necrosis factor drugs (TNF inhibitors). TNF inhibitors are also used to treat chronic inflammatory …
Staff
Dr. Ivona Aksentijevich is an associate investigator in NHGRI Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
… periodic fever syndrome now known as TRAPS (the TNF receptor-associated periodic syndrome). The manuscript … mutations in the extracellular domains of the 55kDa TNF receptor (TNFR1) define a family of dominantly inherited … I, Galon J, Soares M, Mansfield E, Hull K, et al. The TNF receptor-associated periodic fever syndrome (TRAPS): new …
Staff
Dr. Stone is a staff clinician in NHGRI's Inflammatory Disease Section.
… causes an autoinflammatory syndrome responsive to TNF inhibitors . Ann Rheum Dis 2018 Apr; 77(4):612-619. Zhou …
News Release
NIH researchers have identified a treatment that significantly decreases the risk of stroke in children with a rare genetic disease called Deficiency of Adenosine Deaminase Type 2 (DADA2).
… symptoms. A key insight came when researchers noticed TNF staining around inflamed blood vessels in the patients' skin biopsies. That led them to test anti-TNF medications as a possible treatment. "Our success in the … with stroke gives us hope about the potential of anti-TNF agents for improving many other aspects of DADA2," Dr. …
Staff
Dr. Dan Kastner is an NIH Distinguished Investigator in Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
… cause an inherited fever disorder they named TRAPS (the TNF receptor-associated periodic syndrome), and proposed the … mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited …
News Release
Daniel Kastner was named Federal Employee of the Year as part of the 2018 Samuel J. Heyman Service to America Medals program.
… the genetic basis for a recurrent fever syndrome named TNF receptor-associated periodic syndrome (TRAPS). Dr. …
News Release
Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… cancer cells in mice, and then treated the mice with an inhibitor that had seemed most effective in blocking cell migration in zebrafish. The mice treated with the inhibitor developed significantly fewer metastatic tumors …