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News Release
Genomic analyses turned up genes that belong to inflammatory pathways.
… might be a common drug known as a tumor necrosis factor (TNF) inhibitor, prescribed worldwide to treat inflammatory … did blood work, x-rays and bone scans and put him on a TNF inhibitor to see if it could be used for to treat his …
News Release
NHGRI researchers have identified a genomic signature for some aggressive prostate tumors, which may help healthcare providers pinpoint treatment options.
… patients - and prostate tumors - might respond to PARP inhibitor therapy. The research team is now exploring the … the molecular signature predicts positive response to PARP inhibitor treatment better than currently available tools. …
News Release
NIH researchers have discovered a rare and sometimes lethal inflammatory disease - otulipenia - that primarily affects young children.
… had been treated with anti-tumor necrosis factor drugs (TNF inhibitors). TNF inhibitors are also used to treat chronic inflammatory …
Staff
Dr. Ivona Aksentijevich is an associate investigator in NHGRI Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
… periodic fever syndrome now known as TRAPS (the TNF receptor-associated periodic syndrome). The manuscript … mutations in the extracellular domains of the 55kDa TNF receptor (TNFR1) define a family of dominantly inherited … I, Galon J, Soares M, Mansfield E, Hull K, et al. The TNF receptor-associated periodic fever syndrome (TRAPS): new …
Staff
Dr. Stone is a staff clinician in NHGRI's Inflammatory Disease Section.
… causes an autoinflammatory syndrome responsive to TNF inhibitors . Ann Rheum Dis 2018 Apr; 77(4):612-619. Zhou …
News Release
NIH researchers have identified a treatment that significantly decreases the risk of stroke in children with a rare genetic disease called Deficiency of Adenosine Deaminase Type 2 (DADA2).
… symptoms. A key insight came when researchers noticed TNF staining around inflamed blood vessels in the patients' skin biopsies. That led them to test anti-TNF medications as a possible treatment. "Our success in the … with stroke gives us hope about the potential of anti-TNF agents for improving many other aspects of DADA2," Dr. …
Staff
Dr. Dan Kastner is an NIH Distinguished Investigator in Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
… cause an inherited fever disorder they named TRAPS (the TNF receptor-associated periodic syndrome), and proposed the … mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited …
News Release
Daniel Kastner was named Federal Employee of the Year as part of the 2018 Samuel J. Heyman Service to America Medals program.
… the genetic basis for a recurrent fever syndrome named TNF receptor-associated periodic syndrome (TRAPS). Dr. …
News Release
Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.
Event
On November 5-9, 2024, the National Human Genome Research Institute (NHGRI) will participate in the ASHG Annual Meeting - the world's largest human genetics and genomics meeting and exposition.  The annual meeting provides a forum for the presentation and discussion of cutting-edge science in all areas of human genetics.Â