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News Release
Scientists are using an exciting gene editing tool called CRISPR/Cas9 to protect plants from harmful DNA viruses, strengthening the plant's protections.
… Julie Coursen … Scientists are using an exciting gene editing tool called CRISPR/Cas9 to protect plants from … use in many organisms, and this latest iteration develops gene-editing for use in plants. … The November Genome Advance …
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… decision-making for the responsible use of human genome-editing research. … In light of recent advances in gene-editing research and technologies, the National … decision making for the responsible use of human gene-editing research. This initiative examined the clinical, …
News Release
Researchers explored patients', parents' and physicians' perspectives on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease.
… and physicians' perspectives on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease (SCD). … A First-of-its-Kind Study CRISPR-Cas9 is a gene editing technology that researchers have harnessed to …
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those … us to quickly narrow down the search for the specific gene or genes that tell Hydractinia’ s stem cells to become … cell production. The researchers used the CRISPR-Cas9 gene-editing technique to remove Tfap2 from Hydractinia and …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… Genome editing is currently being applied to research on cancer, … targets. Although excitement about the potential for gene therapy has grown tremendously since the discovery of … physicians might eventually be able to prescribe targeted gene therapy to make corrections to patient genomes and …
Staff
Lisa Garrett is an associate investigator and director of the NHGRI Transgenic Mouse Core.
… projects. To this end, she has concentrated on developing gene-editing protocols that will provide more efficient means to … an updated guide for protocols using CRISPR/Cas9 and other gene-editing tools. This guide is provided on the in-house …
For Patients and Families
A list of genetic, orphan and rare diseases under investigation by researchers at or associated with the National Human Genome Research Institute.
… Genetic disorders can be caused by a mutation in one gene (monogenic disorder), by mutations in multiple genes … (multifactorial inheritance disorder), by a combination of gene mutations and environmental factors, or by damage to … Institute.​​ ​ … Genetic Disorder, Genetic Disease, Gene Editing, Genetic Testing, Chromosomes … A list of genetic, …
Policy Issues
Most ethical discussions about genome editing center on human germline editing because changes are passed down to future generations.
… Most of the ethical discussions related to genome editing center around human germline because editing changes … attempted at this time, but that studies that would make gene therapy  safe and effective should continue. 1 , 2  Most … in December 2015 with the International Summit on Human Gene Editing  in Washington, DC. For more information on this …
Policy Issues
Synthetic biology is a field of science that involves redesigning organisms for useful purposes by engineering them to have new abilities.
… biology is similar to another approach called " genome editing " because both involve changing an organism's genetic … other organisms or they could be entirely novel. In genome editing, scientists typically use tools to make smaller … ​ … Synthetic Biology, Synthetic DNA, Genetic Engineering, Gene Editing, Genome Editing … Synthetic biology is a field …
Policy Issues
Patients with genetic disorders and members of the public have diverse about germline genome editing.
… world, have diverse views about whether germline genome editing should be used to prevent or treat genetic disorders. … a survey  to understand the public's feelings about gene editing for newborns that would give them a reduced risk … Though they found some enthusiasm among the public about gene editing, they also found that about two-thirds of U.S. …