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Talking Glossary

A cancer-susceptibility gene is a gene that, when changed (or mutated), gives an individual an increased risk for developing cancer

… Cancer-Susceptibility Gene … A cancer-susceptibility gene is a gene that, when changed (or … have inherited mutations in certain cancer-susceptibility genes have a lifetime risk of cancer that is significantly …

Genetic Disorders

About Breast Cancer

Breast cancer is the second most common cancer in women after skin cancer.

… Breast cancer is the second most common cancer in women after skin … cancer - caused by a mutant gene passed from parents to their children - is rare. Estimates of the incidence of … 10 times more likely to have mutations in BRCA1 and BRCA 2 genes than the general population. Approximately 2.65 percent …

News Release

NIH researchers tackle thorny side of gene therapy

NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.

… conducted research on mice with a rare disease similar to one in humans, hoping their findings may eventually help … "However, we have identified an important safety parameter related to the AAV gene therapy in our mouse models that is … not insert where it would elevate the expression of nearby genes and it did not cause liver cancer. The researchers …

News Release

NHGRI researchers home in on mutation profiles of clear cell endometrial cancer

A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.

… study of clear cell endometrial cancer (CCEC) tumors to date, National Human Genome Research Institute (NHGRI) … her team specialize in basic research aimed at identifying genes that are mutated (changed) in the tumors of patients … but clinically aggressive form of endometrial cancer. … Related Content … NHGRI researchers home in on mutation …

News Release

TCGA bladder cancer study reveals potential drug targets, similarities to several cancers

Investigators with The Cancer Genome Atlas Research Network have identified new potential therapeutic targets for a major form of bladder cancer.

… for a major form of bladder cancer, including important genes and pathways that are disrupted in the disease. They … mechanisms underlying bladder cancer, which is estimated to cause more than 15,000 deaths in the United States in … programs, visit www.nih.gov . … New Research Directions … Related Content … TCGA bladder cancer study reveals potential …

Educational Resources

First Degree Relative

A first degree relative is a family member who shares about 50 percent of their genes with a particular individual in a family.

… is a family member who shares about 50 percent of their genes with a particular individual in a family. … Family … Genetic Disorders, Ancestry, Healthcare, Genealogy, Genes … A first-degree relative is a family member who shares … is a family member who shares about 50 percent of their genes with a particular individual in a family. … Educational …

Genetic Disorders

About Colon Cancer

Colon cancer is a malignant tumor of the large intestine that affects both men and women.

… Colon cancer, a malignant tumor of the large intestine, affects … of colon cancer. The risk of inheriting these mutated genes from an affected parent is 50 percent for both males … Scientists have discovered several genes contributing to a susceptibility to two types of colon cancer: FAP …

Genetic Disorders

About Skin Cancer

Skin cancer is the most common type of cancer in the United States.

… type of cancer in the United States. An estimated 40 to 50 percent of Americans who live to age 65 will have skin … eyes - although anyone can get skin cancer. Skin cancer is related to lifetime exposure to UV radiation, therefore most … in this form of melanoma. Studies have also implicated genes on chromosomes 1 and 12 in cases of familial melanoma. …

News Release

The Cancer Genome Atlas publishes results for bile duct, uterine and breast cancer

The TCGA network describes uterine and bile duct cancer.

… NHGRI Communications and Public Liaison Branch … The Cancer Genome Atlas (TCGA), a program co-funded by the … TCGA's dataset can provide a more complete picture of how to prevent, diagnose and treat specific cancer types. The … https://cancergenome.nih.gov/ https://www.cancer.gov/ … Related Content … The Cancer Genome Atlas publishes results …

15 Ways Genomics Influences Our World

Cancer Genomics

Genomics is transforming how we study, diagnose and treat cancer.

… Genomics is transforming how we study, diagnose and treat cancer. … Did you know that we are increasingly able to detect cancers by testing just a blood sample? Or that we … that some cancers have mutations in the same group of genes, even though they may have started in completely …