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- Ethical, Legal and Social Implications (ELSI) Research Program5
- Genomics-Enabled Learning Health Systems (gLHS)2
- Genetic Architecture of Complex Traits1
- Genome Technology Program5
- Human Genome Reference Program (HGRP)2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Encyclopedia of DNA Elements (ENCODE) Project1
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- Genomic Innovator Awards1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)3
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
- Developmental Genotype-Tissue Expression (dGTEx)1
- Multi-Omics for Health and Disease (Multi-Omics)1
News Release
A new study highlights how genomic mutations that cause mitochondrial disease may also compromise affected people's immune response.
… disease may also compromise affected people's immune response. … Based on clinical data from patients with … disease in T-cells. T-cells play important roles in human immune response. The mutations resulted in an increased …
News Release
Researchers find weaker immune response to viral infections in children with mitochondrial disorders
NIH researchers analyzed the gene activities of immune cells in children with mitochondrial disorders and found that their B cells, which produce antibodies to fight viral infections, are less able to survive cellular stress.
… One of the first human studies on how mitochondrial function impacts immune cells to guide future treatments. … In a new study, … disorders led to a weaker and less diverse antibody response to viral infections. The study, published in …
News Release
A new study offers insights into why some people's hair goes gray in response to a serious illness or chronic stress.
… offers insights into why some people's hair goes gray in response to a serious illness or chronic stress. Researchers … to hair color and the genes that control the body's immune system. They published their findings May 3, 2018, in … of the Genetic Disease Research Branch at NIH's National Human Genome Research Institute (NHGRI). "These results may …
News Release
Researchers at NHGRI have discovered an immune mechanism in humans that perceives threats and was found only in plants.
… don't seem to have much in common. When it comes to their immune systems, however, they might be more similar than their exteriors suggest. Researchers at the National Human Genome Research Institute (NHGRI) have discovered an … and white blood cells to annihilate the pathogen - a response, in some cases, that's orchestrated by a complex …
News Release
The skin microbiota plays an intricate role in the human immune system, directing many immune functions and defending against bacterial pathogens.
… Bruce Agnew … The billions of microbes that reside on human skin - probably more than 10 billion microbial cells on … the skin microbiota plays an intricate role in the human immune system, actually directing many immune functions and … of T cells, key actors in directing immune system response. In fact, the richest concentrations of immune cells …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… to six research institutions to create a database of human cellular responses, the Library of Integrated … the Data and Signature Generating Centers. The National Human Genome Research Institute (NHGRI) and the National … and analyze cellular function and molecular activity in response to perturbing agents - such as drugs and genetic …
News Release
NIH investigators have discovered that genomic switches of a blood cell are key to regulating the human immune system.
… genomic switches of a blood cell are key to regulating the human immune system. The findings, published in Nature today, open … to communicate with other cells and to mount an immune response. But the researchers' most striking observation was …
News Release
How well cancer patients fare after chemotherapy can be affected by their social interaction with other patients during treatment.
… according to a new study by researchers at the National Human Genome Research Institute (NHGRI), part of the National … occurred, but hypothesize that it may be related to stress response. "When you're stressed, stress hormones such as adrenaline are released, resulting in a fight or flight response," Mr. Lienert said. "If you are then unable to fight …
Clinical Research
A Longitudinal Natural History Study of Children with Mitochondrial Disease (at the NIH Clinical Center).
… can affect many different parts of the body, including the immune system and its ability to respond to infection. … how Inborn Errors of Metabolism affect the function of the immune system. … A Longitudinal Natural History Study of …
Educational Resources
An antibody is a protein component of the immune system that circulates in the blood, recognizes foreign substances like bacteria and viruses, and neutralizes them.
… Antibody … An antibody is a protein component of the immune system that circulates in the blood, recognizes … like bacteria and viruses, and neutralizes them. … Immune System, Bacteria, Virus, Blood, Circulation, Disease, … Antigen … An antibody is a protein component of the immune system that circulates in the blood, recognizes …