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- Genome Technology Program3
- Impact of Genomic Variation on Function (IGVF) Consortium1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
- Ethical, Legal and Social Implications (ELSI) Research Program1
Policy Issues
Synthetic biology is a field of science that involves redesigning organisms for useful purposes by engineering them to have new abilities.
… Synthetic biology is a field of science that involves … useful purposes by engineering them to have new abilities. Synthetic biology researchers and companies around the world … sensing something in the environment, are common goals of synthetic biology projects. Some examples of what scientists …
Staff
Dr. James Inglese is an adjunct investigator in NHGRI's Metabolic Medicine Branch.
… of a diversity of chemical substances such as large synthetic compound libraries, existing pharmaceuticals, and naturally …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… Golub team will study up to 50 cell types perturbed by a large number of chemical compounds and genetic reagents that …
Genetic Disorders
Colon cancer is a malignant tumor of the large intestine that affects both men and women.
… Colon cancer, a malignant tumor of the large intestine, affects both men and women. In the United … each year. … Colon cancer, a malignant tumor of the large intestine, affects both men and women. In the United … Colon Cancer … Colon cancer is a malignant tumor of the large intestine that affects both men and women. … Colon …
News Release
In a new large-scale genetic analysis, National Institutes of Health (NIH) scientists have found set of small RNA molecules, called microRNAs, in human pancreatic cells that are strongly associated with type 2 diabetes.
… identifies new molecules involved in diabetes. … In a new large-scale genetic analysis, scientists have found a set of … and first author of the study. … About NHGRI and NIH … Large-scale genetic analysis shows microRNAs in human pancreas associated with diabetes … In a new large-scale genetic analysis, National Institutes of Health …
Genetic Disorders
Trimethylaminuria is a metabolic condition in which an individual is not able to convert trimethylamine into a compound called trimethylamine N-oxide.
… an individual is not able to convert trimethylamine into a compound called trimethylamine N-oxide. Trimethylaminuria, … and support in the past 30 years. … Trimethylamine is the compound that gives fish the fishy odor. Trimethylamine … an individual is not able to convert trimethylamine into a compound called trimethylamine N-oxide. ​ … …
News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… the disease. Using this model, they have now tested a drug compound that has successfully corrected the malfunctioning … Gaucher disease. Researchers then tested a small molecule compound on the damaged cells, which resulted in enhanced … disorder Parkinson's disease. NHGRI also coordinated a large international study determining that GBA alterations …
Staff
Dr. Ajay Pillai is a program director in the Division of Genome Sciences at the National Human Genome Research Institute.​
… … Biography … Ajay Pillai, Ph.D. … Ajay Pillai, Molecular Libraries Program, NIH Common Fund, mental health, bioinformatics … Ajay Pillai, Molecular Libraries Program, NIH Common Fund, mental health, …
Talking Glossary
cDNA (short for copy DNA; also called complementary DNA) is synthetic DNA that has been transcribed from a specific mRNA through a reaction using the enzyme reverse transcriptase
… (short for copy DNA; also called complementary DNA) is synthetic DNA that has been transcribed from a specific mRNA … (short for copy DNA; also called complementary DNA) is synthetic DNA that has been transcribed from a specific mRNA … (short for copy DNA; also called complementary DNA) is synthetic DNA that has been transcribed from a specific mRNA …
Research Funding
The Genomic Variation Program supports large-scale studies of human genetic variation.
… and phenotype. The Genomic Variation Program supports large-scale studies of human genetic variation as part of … (SNPs), indels, and other forms of genetic variation on a large scale across the genome. Developing high-resolution … variation and haplotypes. Developing methods for the large-scale experimental and statistical analysis of SNPs, …