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Staff
Lisa Garrett is an associate investigator and director of the NHGRI Transgenic Mouse Core.
… Lisa Garrett is a staff scientist and director of the NHGRI Transgenic Mouse Core at the NIH. In 1984, she received her … Molecular Oncology at NCI, Frederick, Maryland. generating transgenic mice for models of cancer. At this time, she started her …
Educational Resources
Transgenic means that one or more DNA sequences from another species have been introduced by artificial means.
… Transgenic … Transgenic means that one or more DNA sequences from another … Cloning, Deoxyribonucleic Acid (DNA), Gene, Germ Line … Transgenic refers to an organism or cell whose genome has … DNA sequences from another species by artificial means. Transgenic organisms are generated in the laboratory for …
News Release
Researchers have discovered that FGF21 is elevated in mice with liver disease that mimics the same condition in patients with methylmalonic acidemia.
… growth factor 21 (FGF21), is extremely elevated in mice with liver disease that mimics the same condition in … in their mitochondria, specifically in the liver. The MMA mice also allowed them to study the response to … News Feature: Elevated hormone flags liver problems in mice with methylmalonic acidemia (MMA) … Researchers have …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… to impede or halt this deadly process. They have developed transgenic zebrafish as a live animal model of metastasis - … of times more quickly than mammalian models such as mice (although not nearly so fast as flies). It can be made transgenic by injecting a small sequence of foreign DNA into …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… what that gene normally does. Humans share many genes with mice. Consequently, observing the characteristics of knockout mice gives researchers information that can be used to better … disease in humans. Examples of research in which knockout mice have been useful include studying and modeling different …
News Release
NHGRI researchers are studying the link between Parkinson's disease, and a rare disorder, Gaucher disease, by cross-breeding mice with the disease mutations.
… and a rare disorder, Gaucher disease, by cross-breeding mice to carry human mutations causing each of the two … extra copies of a mutated form of alpha-synuclein. These mice were then mated with mice missing a copy of the GBA1 gene. The resulting mice - …
News Release
NIH researchers identified a novel role for a gene known as heat shock protein 60, finding it is critical in tissue regeneration and wound healing.
… of the Hsp60 protein to a puncture wound in diabetic mice stimulated complete healing after only 21 days. Mice without the treatment did not show improvement over the … Although promising, this finding has only been shown in mice and is yet to be tested in humans. "We hope that topical …
Educational Resources
An animal model is a non-human species used in medical research because it can mimic aspects of a disease found in humans.
… humans. … Biomedical Research, Ethics, Animal Experiments, Mice, Rats, Experiment … An animal model is a non-human … process or disease found in humans. Animal models (e.g., mice, rats, zebrafish and others) are sufficiently like …
Educational Resources
The zebrafish is a member of the minnow family of fish.
… member of the minnow family of fish. … Animal Model, Gene, Transgenic, Candidate Gene, Genetic Engineering, Knockout … …
Educational Resources
Fact sheets explaining complex concepts in genomics research to a non-scientific audience.
… DNA Microarray, DNA Sequencing, Epigenomics, Knockout Mice, Newborn Screening, Cost Of Sequencing A Human Genome, X …