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A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division.
… Tumor Suppressor Gene … A tumor suppressor gene directs the production of a protein … … BRCA1, BRCA2, Cancer, Oncogene, Cell, Gene, Mutation … A tumor suppressor gene encodes a protein that acts to regulate …
News Release
NHGRI researchers have identified a genomic signature for some aggressive prostate tumors, which may help healthcare providers pinpoint treatment options.
… fix damage to DNA. The research team used whole genome sequencing, a process that reveals the complete DNA make-up of an organism at a single time, to look at tumor-specific mutations in aggressive prostate cancer. The … genomic signatures, Elaine Ostrander Ph.D., whole genome sequencing, BRCA2 gene, PARP inhibitors … NHGRI researchers …
News Release
NIH-funded researchers completed the PanCancer Atlas from over 10,000 tumors representing 33 types of cancer.
… by healthy cells (in pink), illustrating a primary tumor spreading to other parts of the body through the … "The PanCancer Atlas effort complements the over 30 tumor-specific papers that have been published by TCGA in the … at NCI. The project focused not only on cancer genome sequencing, but also on different types of data analyses, …
Media Availability
Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.
… Nature Medicine . Their work is supported by the Clinical Sequencing Exploratory Research program at the National Human … are located. Initially, they showed that two different tumor sample storage methods produced comparable DNA … and spoke to experts to develop a database of 121 tumor genomic alterations that could have therapeutic, …
Educational Resources
Shotgun sequencing is a laboratory technique for determining the DNA sequence of an organism's genome.
… Shotgun Sequencing … Shotgun sequencing is a laboratory technique for determining the DNA … an organism's genome. … Deoxyribonucleic Acid (DNA), DNA Sequencing, Genome, Human Genome Project … Shotgun sequencing …
Genetic Disorders
Colon cancer is a malignant tumor of the large intestine that affects both men and women.
… Colon cancer, a malignant tumor of the large intestine, affects both men and women. In … are diagnosed each year. … Colon cancer, a malignant tumor of the large intestine, affects both men and women. In … cancer? … About Colon Cancer … Colon cancer is a malignant tumor of the large intestine that affects both men and women. …
15 Ways Genomics Influences Our World
Advances in genomics are reducing the cost of genome sequencing by a million-fold.
… Advances in genomics are reducing the cost of genome sequencing by a million-fold. … Did you know that your genome … DNA, including a million-fold reduction in the cost for sequencing a human genome. Continually improving the accuracy … sequences. As a result, we now have multiple methods for sequencing DNA quickly and inexpensively (see videos in …
Educational Resources
DNA sequencing is a laboratory technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA molecule.
… DNA Sequencing … DNA sequencing is a laboratory technique used to determine the … … Adenine, Cytosine, Guanine, Thymine, ACGT, DNA, DNA Sequencing … DNA sequencing refers to the general laboratory …
Research Funding
Coordinates activities across the Genome Sequencing Program components
… The National Human Genome Research Institute's Genome Sequencing Program Coordinating Center (GSPCC) was funded in 2016 to coordinate activities across the Genome Sequencing Program components. … The GSPCC has both … and administrative activities including: Tracking genome sequencing and analysis costs; data production and …
Fact Sheets
Estimated cost of sequencing the human genome over time since the Human Genome Project.
… have led to substantial reductions in the cost of genome sequencing. The underlying costs associated with different methods and strategies for sequencing genomes are of great interest because they … scrutiny and attention have been given to genome-sequencing costs and how they are calculated since the …