Search Results
Educational Resources
An animal model is a non-human species used in medical research because it can mimic aspects of a disease found in humans.
… humans. … Biomedical Research, Ethics, Animal Experiments, Mice, Rats, Experiment … An animal model is a non-human … process or disease found in humans. Animal models (e.g., mice, rats, zebrafish and others) are sufficiently like …
Event
The National Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International Mouse Phenotyping Consortium (IMPC)'s annual meeting at the Rockville Hilton in Rockville, Maryland, on November 19, 2019.
… Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International … Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International … Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International …
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
… some aspect of human physiology or disease. … Mouse Model, Knockout Mouse, Genetic Engineering, Laboratory Experiment, … of different model organisms are used in this regard, but mice are especially useful because they share mammalian …
Educational Resources
The zebrafish is a member of the minnow family of fish.
… Gene, Transgenic, Candidate Gene, Genetic Engineering, Knockout … The zebrafish is a member of the minnow family of …
News Release
NIH researchers demonstrated that gene therapy may be the best method for correcting the single faulty gene that causes Niemann-Pick disease, type C1.
… of Health (NIH) researchers have demonstrated in mice that gene therapy may be the best method for correcting … involved inserting a functional copy of the NPC1 gene into mice with the disease; the treated animals were then found to … types of Niemann-Pick disease; this study focused on mice that had been bred with a faulty NPC1 gene to model …
Research Funding
MorPhiC aims to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene by using in-vitro multicellular systems.
… Huangfu Sloan Kettering Institute Center for scalable knockout and multimodal phenotyping in genetically diverse … Gene-Phenotype Associations Using Omic Data from Gene Knockout and Human Phenotype Studies U01 HG013177 … The 2020 …
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… evolutionary time and the genomic landscapes of humans and mice, an international group of researchers has found … better understand how similarities and differences between mice and humans are written in their genomes. … Their … used to control gene activity have many similarities in mice and humans, and have been conserved, or continued, …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… associated with gene therapy. They conducted research on mice with a rare disease similar to one in humans, hoping … In prior MMA gene therapy studies, researchers showed that mice bred to develop the condition could be restored to … by AAV gene therapy injection shortly after birth. The mice in the study survived into adulthood and were free from …
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… Transgenic Mouse Core uses CRISPR to generate laboratory mice with specific gene alterations for the study of human … NHGRI researchers take advantage of this resource. The Knockout Mouse Project (KOMP) is an National Institutes of … that NHGRI helped develop. It was designed to generate mice containing mutations in every gene of the mouse genome. …
News Release
NIH is launching a program, Molecular Phenotypes of Null Alleles in Cells (MorPhiC), to better understand the function of every human gene and generate a catalog of the molecular and cellular consequences of inactivating each gene.
… investigating the consequences of knocking out genes in mice at the level of tissues and organs as part of the Knockout Mouse Program. Another effort is applying new … for Cancer Research, New York City Center for scalable knockout and multimodal phenotyping in genetically diverse …