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- Genome Technology Program3
- Impact of Genomic Variation on Function (IGVF) Consortium3
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)2
- Developmental Genotype-Tissue Expression (dGTEx)1
- Ethical, Legal and Social Implications (ELSI) Research Program4
- Genomics-Enabled Learning Health Systems (gLHS)1
Research Funding
The Encyclopedia of DNA Elements (ENCODE) Pilot Project launched in September 2003 to identify all functional elements in the human genome sequence.
… of DNA Elements (ENCODE) in September 2003 to carry out a project to identify all functional elements in the human … of non-exonic conservation with respect to the orthologous mouse genomic sequence (see below), for a total of nine … that showed less than 75 percent base alignment with mouse sequence were discarded. For the remaining subwindows, …
News Release
NHGRI researchers are studying the link between Parkinson's disease, and a rare disorder, Gaucher disease, by cross-breeding mice with the disease mutations.
… controlling movement. Midbrain neurons from the new mouse model. The green shows the clumped alpha-synuclein. … In the study, the authors used a Parkinson's disease mouse model that carried extra copies of a mutated form of … is different about the cross-bred mice. Ultimately, this mouse model can be used to develop and evaluate new …
About Genomics
The Human Genome Project was an inward voyage of discovery led by an international team of researchers looking to sequence and map all the genes of our species.
… The Human Genome Project (HGP) is one of the greatest scientific feats in history. The project was a voyage of biological discovery led by an … October 1990 and completed in April 2003, the Human Genome Project’s signature accomplishment – generating the first …
Fact Sheet
A fact sheet detailing how the project began and how it shaped the future of research and technology.
… The human genome sequence generated by the Human Genome Project was actually a patchwork of multiple people whose … of mostly European ancestry. … How did the Human Genome Project affect biological research in general? The Human … bacterium E. coli , baker’s yeast, fruit fly, nematode and mouse. The project’s architects and participants hoped the …
Virtual Exhibit
The Human Genome Project changed traditional understandings of how and why scientific research is conducted. It was, however, not without its detractors. Early in 1990, there was an effort to stop funding for the nascent Human Genome Project, in the form of a letter writing campaign.
… letter, which circulated and spurred the anti-Human Genome Project letter campaign. The first line of the letter reads “The human genome project: mediocre science, terrible science policy.” … … of Kentucky Medical Center, argued that the Human Genome Project would not draw new professionals in science and …
The Genomics Landscape
In the June 2019 edition of The Genomics Landscape, NHGRI Director Eric Green details the legacy of the Human Microbiome Project as it reaches completion.
… catalyzed the launching of the NIH Human Microbiome Project (HMP). In 2007, the NIH Common Fund initiated the HMP … multiple initiatives, including the International HapMap Project , the 1000 Genomes Project , the Genomic Resources Program, the Centers of …
Research Funding
The Genotype-Tissue Expression (GTEx) Project will create a resource that researchers can use to study how inherited changes in genes lead to common diseases
… 2010 (See: NIH launches Genotype-Tissue Expression project ), GTEx will create a resource that researchers can … gift of tissues and medical information to the GTEx project makes possible research that will help improve our … cure these diseases in the future. In addition, the GTEx project includes a study to explore the effectiveness of the …
Research at NHGRI
The Democratizing Education for Sickle Cell Disease Gene Therapy project developed patient-focused educational materials for the sickle cell community.
… Education for Sickle Cell Disease Gene Therapy Project, which is led by NHGRI in partnership with other … therapy and biomedical research communities. … This project created patient-focused education materials for the … Education for Sickle Cell Disease Gene Therapy Project, which is led by NHGRI in partnership with other …
Staff
Lisa Garrett is an associate investigator and director of the NHGRI Transgenic Mouse Core.
… is a staff scientist and director of the NHGRI Transgenic Mouse Core at the NIH. In 1984, she received her M.S. at … 1994 and completed her thesis, The Tissue - Specificity of Mouse Ets-1 Regulatory Region in a Transgenic Model. In 1994, … supervisor in the NHGRI Embryonic Stem Cell and Transgenic Mouse Core and became director in 1997. Ms. Garrett oversees …
News Release
NIH and Inova Health are launching The Genomic Ascertainment Cohort, a pilot project that will examine gene and gene variant influence on phenotypes.
… Jeannine Mjoseth … Databases such as the 1000 Genomes Project and the Exome Aggregation Consortium (ExAC) harbor … The Genomic Ascertainment Cohort (TGAC), a two-year pilot project that will allow them to recall genotyped people and … traits, such as height, eye color or blood type. The project reverses a long-standing research paradigm of …