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In biology, an organ (from the Latin "organum" meaning an instrument or tool) is a collection of tissues that structurally form a functional unit specialized to perform a particular function.
Educational Resources
In situ hybridization is a laboratory technique in which a single-stranded DNA or RNA sequence called a probe is allowed to form complementary base pairs with DNA or RNA present in a tissue or chromosome sample.
… form complementary base pairs with DNA or RNA present in a tissue or chromosome sample. … In Situ Hybridization, DNA, … In this technique, a biological sample consisting of tissue sections, cells or chromosomes from an individual is …
News Release
NIH researchers researchers and collaborators have gained some key insights into the biological inner-workings of regrowing a body, the evolution of aging and a unique method to dispose of aging cells, by studying the genomes of a hermit crab (Hydractinia symbiolongicarpus).
… abilities, such as growing a whole new body from a tissue fragment. A regenerative role for senescence stands in … that Hydractinia has a special group of stem cells for regeneration. Stem cells can transform into other types of … cells throughout their lifetimes. Hydractinia stores its regeneration-driving stem cells in the lower trunk of its …
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… defect known as a coloboma, which is a missing piece of tissue in the lens, iris or retina. At the largest zebrafish …
News Release
NIH researchers have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The study, led by scientists at the National Human Genome Research Institute (NHGRI), found that individuals diagnosed with ADHD had differences in genes that code for known chemicals that brain cells use to communicate.
… this is the first study to use postmortem human brain tissue to investigate ADHD. Other approaches to studying … studies are rare because of the limited donation of brain tissue but are incredibly valuable because they provide …
Staff
Dr. Shawn Burgess is the co-deputy director of NHGRI's Intramural Research Program.
… in any biological process. Hearing development and regeneration remains an area of interest in the DGS, used to … phenotypes will range from early development to adult tissue regeneration. This unique resource will accelerate discovery …
Fact Sheets
Cloning describes a number of different processes that can be used to produce genetically identical copies of a biological entity.
… cloning. The richest source of embryonic stem cells is tissue formed during the first five days after the egg has …
Event
On November 16-17, 2023, the National Human Genome Institute will co-sponsor a workshop, Advances in the Genetic Architecture of Complex Human Traits, to take a historically grounded and forward-looking approach towards dissecting the genetic architecture of complex traits in humans.
… of other genomic resources such as cell lines and tissue collections?  Roundtable 1 – What’s missing from our … biology, as well as immunology, implicate regulation of regeneration / wound healing / scarring processes as a factor …
Genetic Disorders
Neurofibromatosis is a genetic neurological disorder that can affect the brain, spinal cord, nerves and skin.
… (pea-sized bumps) that can grow either on the nerve tissue, under the skin or on many nerve tissues. …
News Release
Researchers have identified genomic mutations for Carey-Fineman-Ziter syndrome, a congenital myopathy with facial weakness, a cleft palate and scoliosis.
… (myotubes) during the development of an embryo and the regeneration of muscle cells after injury. The study was …