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Staff
Dr. Neil Hanchard is a clinical investigator within the Center for Precision Health Research (CPHR) and head of the Childhood Complex Disease Genomics Section within the CPHR.
Staff
Dr. Sharon Milgram is an adjunct investigator in the Genetics and Molecular Biology Branch at the National Human Genome Research Institute.
… biochemical assays to physiological assays in knock-out mice. … Altschuler Y, Hodson C, Milgram SL. The apical … chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol Cell Biol , …
News Release
NHGRI researchers will present four platform talks and 55 posters to highlight the institute's diverse portfolio at the 65th annual meeting of ASHG.
… alleles in the vitamin B12 receptor, CD320, in humans and mice. (Molecular Basis of Mendelian Disorders) 2819W. … Disorders) *2271T. Oleg Schelochkov: A Zebrafish Knockout of Argininosuccinate Lyase Separates Ureagenic and … carriers. (Metabolic Disorders) *2313T. Peter J. McGuire: Mice lacking Cox10 in T-lymphocytes recapitulate the immune …
News Release
Researchers have identified genomic mutations for Carey-Fineman-Ziter syndrome, a congenital myopathy with facial weakness, a cleft palate and scoliosis.
… each family, only the gene MYMK was common to all three. A knockout mouse model (genomically altered mice that are bred to lack a specific gene) displayed a … muscle development, leading to early death of the newborn mice, making this gene a promising candidate for further …
News Release
Scientists drafted the blueprint for how to build a common goldfish. Now they'll use it to find out what gives ornamental goldfish their nuanced features, gaining insight into human health.
… 60 million years ago, a similar distance as between mice and humans. The common carp's DNA was already sequenced. … or remove a gene from an animal. Researchers use this "knockout" technique to study how genes affect animals. Yet … new functions for genes. This is a natural complement to ‘knockout' laboratory studies.  Co-first author Dr. Yoshihiro …
News Release
Researchers show critical association between diabetes and previously unlinked ZRANB3 gene.
… make the ZRANB3 gene inoperative in zebrafish (called a ‘knockout’). They also used biological tools to reduce the … such β-cell death, the researchers took β-cell cells from mice and performed a similar knockdown of the ZRANB3 gene as …
Staff
Dr. Charles Venditti is a chief and senior investigator of NHGRI's Metabolic Medicine Branch.
… acid metabolism in model organisms, including roundworms, mice and zebrafish. Using a translational research approach, … all the studies are striking: while the untreated Mut-/- mice uniformly perish in early life, the Mut-/- mice that receive AAV gene therapy with any of the section's …
Staff
Dr. Raman Sood is an associate investigator in the Translational and Functional Genomics Branch and director of the Zebrafish Core at the National Human Genome Research Institute.
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… Dr. Sood has generated and characterized gene knockout mutants for several important hematopoietic genes. … CRISPR/Cas9 to generate single or multiple gene knockout mutants in zebrafish. To date, the core has … SM. Highly-efficient Cpf1-mediated gene targeting in mice following high concentration pronuclear injection . G3. …
File
… or undiagnosed diseases–Genes depleted for LoFvariants–Knockout genes that generate a phenotype in mice–Gene families targetable by drugs•Criteria for …
The Genomics Landscape
In the February 2018 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the new director of NHGRI's Division of Genome Sciences.
… Fund Programs - the Human Microbiome Project (HMP), the Knockout Mouse Phenotyping (KOMP2) Program; the Human … Goes Viral NIH Scientists Find Microbes on the Skin of Mice Promote Tissue Healing, Immunity Researchers Study …