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- Genetic Architecture of Complex Traits1
- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
- Developmental Genotype-Tissue Expression (dGTEx)1
Health FAQ
Discuss these questions with your doctor or health care provider.
… Education Project welcomes your feedback about the sickle cell disease gene therapy resources. Please email your … so you can know the risk of your child having sickle cell trait or sickle cell disease. Genetic counselors are trained …
News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.
… of Health, asked patients, parents and physicians in the sickle cell disease community what they wanted and needed to know … treatments, which appear to provide a potential for sickle cell, are among the most widely publicized medical …
Fact Sheet
Understanding gene therapy for sickle cell disease
… Sickle cell disease is the most common inherited blood disorder in … there are only a handful of options to manage or treat sickle cell disease.  Now, researchers are developing new and …
Research Funding
Building upon a foundation of quantitative genetics laid over a century ago, applying modern genomic approaches to resolve how genetic and non-genetic factors shape variation in human diseases and traits.
… goal of human genetics is to decompose the sources of trait variation into constituent causal factors. The hope is … the interplay of genetic and non-genetic factors on trait variation. These issues have recently risen to the fore … outreach activities.  … Webinar Series: Complex Trait Genetics Following on the heels of NHGRI’s workshop …
Fact Sheet
Sickle cell disease resources for healthcare providers
… Education Project welcomes your feedback about the sickle cell disease gene therapy resources. Please email your … to promote your general understanding of gene therapy for sickle cell disease. We encourage you to use these …
Educational Resources
A cell is the basic building block of living things.
… Cell … A cell is the basic building block of living things. … Eukaryotes, Prokaryotes, Basic Biology … A cell is the basic building block of living things. All cells … to contain between 10 and 100 trillion cells. … A cell is the basic building block of living things. … …
Fact Sheet
A variety of approaches target the blood stem cells to relieve or reduce your symptoms of sickle cell disease.
… these components differ and other treatment options for sickle cell disease, such as bone marrow transplant.  Each of these … target the blood stem cells to reduce your symptoms of sickle cell disease.  Gene therapies use your own stem cells, …
Educational Resources
A stem cell is a cell with the potential to form many of the different cell types found in the body.
… Stem Cell … A stem cell is a cell with the potential to form many of the different cell types found in the body. … Cell, Mitosis … A stem cell …
Staff
Vence Bonham is the acting deputy director for NHGRI and an associate investigator in NHGRI's Social and Behavioral Research Branch.
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… health inequities. The Bonham group also studies sickle cell disease, a condition that will be impacted by emerging … populations. The Bonham group also studies sickle cell trait and sickle cell disease, a condition with applications …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… complex that packages DNA into chromosomes in the cell - to better understand how the genome works. A better … are managed. … Chromatin influences gene activity in a cell by controlling access to the genes and regulatory … off. Chromatin organization can also influence both normal cell development - whether a cell might become a liver, …