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Fact Sheet
Ribonucleic acid (RNA) is an essential molecule that performs many roles in the cell, from carrying the instructions to make proteins to regulating genes.
… is RNA made? RNA molecules are made by a process called transcription . In RNA, there are four different nucleotides, … nucleotide that makes up the DNA strand.  During transcription, the DNA serves as a template, and the RNA … after infecting a cell. This process is known as reverse transcription .  A type of genetic element called a …
FAQ
Frequently asked questions related to the Informational Session on the Renewed ELSI Funding Opportunities: R01 (PAR-23-293), R21 (PAR-23-294), and R03 (PAR-23-295).
Staff
Dr. Edward Giniger is an adjunct investigator in NHGRI's Genetics and Molecular Biology Branch.
… and Giniger, E. Alternative splicing of lola generates 19 transcription factors controlling axon guidance in … E. A genome-wide analysis reveals that the Drosophila transcription factor, Lola, promotes axon growth in part by …
Infographic
The X chromosome is part of sexual development and many other biological processes, including how some cats get their distinctive coat colors.
… one of the X chromosomes is inactivated . This stops transcription (creation of RNAs) from occurring, ensuring … chromosomes are rare and will have an XXY genotype. …  … Transcription … Related Video … Downloads … X Chromosome …
Staff
Dr. Laura Elnitski is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute.
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… Jin, V.X., Farnham, P.J., Jones, S.J. Locating mammalian transcription factor binding sites: A survey of computational …
Research Training
Two-year fellowships for M.D.s and Ph.D.s in cytogenetics, biochemical genetics and molecular genetics.
Research at NHGRI
NHGRI researchers develop freely available software and analysis tools to help researchers around the world analyze and explore their genomic data.
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… ZFN must be engineered for each new target DNA sequence. Transcription activator-like effector nucleases (TALENs) In 2009, a new class of proteins called Transcription Activator-Like Effector Nucleases (TALENs) …  arrived to the genome editing scene. Similar to ZFNs, transcription activator-like effector nucleases (TALENs) are …
FAQ
Frequently asked questions from the May 23, 2023 informational webinar, ELSI Research and the New NIH Data Management and Sharing (DMS) Policy.
Staff
Dr. Mike Pazin is a program director in the Division of Genome Sciences at the National Human Genome Research Institute.
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… Epub 2011 Sep 13. PMID: 21931736  IL-10 transcription is negatively regulated by BAF180, a component …