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William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… factor SOX10 result in neural crest stem cell defects in mice that accurately model enteric nervous system … used comparative genomic sequencing analyses and zebrafish transgenic technologies to reveal cis-acting genomic elements … gene therapy can increase the lifespan of NPC1 mutant mice, and also improve neuronal and liver abnormalities. …
Staff
Dr. Raman Sood is an associate investigator in the Translational and Functional Genomics Branch and director of the Zebrafish Core at the National Human Genome Research Institute.
… in situ hybridization, generation of genetic mutants and transgenic lines, cryopreservation, in vitro fertilization to … and maintain several commonly used wild type, mutant and transgenic zebrafish lines. Since its inception, the core has … SM. Highly-efficient Cpf1-mediated gene targeting in mice following high concentration pronuclear injection . G3. …
Research at NHGRI
The Genetics and Molecular Biology Branch uses genomic technologies to study the human genome and other organisms and disease mechanisms.
… investigators access to state-of-the-art bioinformatic, transgenic-animal, flow-cytometry, genomic and cytogenetic …
Jobs at NHGRI
Funded postdoctoral positions are available in the laboratory of Dr. Shawn Burgess, within NHGRI's Translational and Functional Genomics Branch.
… microscopy, flow cytometry, cytogenetics, and transgenic mouse and zebrafish cores, allowing for broad …
Jobs at NHGRI
Postdoctoral positions are available in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch of the National Human Genome Research Institute, at NIH.
… copy number analysis, flow cytometry, cytogenetics and a transgenic mouse core, offers the trainee wide latitude in …
Jobs at NHGRI
Postdoctoral positions are available in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch of the National Human Genome Research Institute, at NIH.
… copy number analysis, flow cytometry, cytogenetics, and a transgenic mouse core, offers the trainee wide latitude in …
Staff
Dr. David Bodine is the chief of and senior investigator in NHGRI's Genetics and Molecular Biology Branch.
… Devlin EE, Dacosta L, Mohandas N, Elliott G, Bodine DM. A transgenic mouse model demonstrates a dominant negative … of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced …
News Release
A new study offers insights into why some people's hair goes gray in response to a serious illness or chronic stress.
… Decreasing the expression of the MITF gene in the mutant mice increased the interferon signature in melanocyte stem … of melanocytes. Overexpression of SOX10 in these mice caused hair graying. Combining the two mouse models by mating the mice produced greater amounts of gray hair. This combined …
News Release
Research points to the effects of nutrients in how DNA mutates in the mitochondria.
… life.” The researchers first searched for mutations in mice that were bred to be genetically identical. That way, … that were already present. “You could think of all the mice we studied as being large groups of identical twins,” … “The traits and characteristics we were looking at in the mice reflect a combination of genes and environment, so in …
The Genomics Landscape
In the January 2024 issue of The Genomics Landscape, NHGRI Director Eric Green announces the appointment of Dr. Adam Phillippy as the founding director of the Center for Genomics and Data Science Research (CGDSR).
… the cellular receptor for SARS-CoV-2. In the edited mice, expression patterns of ACE2 were similar to those in …