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News Release
NIH researchers searched for how the body signals the lack of oxygen in melanoma skin cancer.
… Jeannine Mjoseth … Cancerous tumors are voracious. Once they have consumed all the oxygen … trials are focused on targeting genetic changes in tumors and helping to boost one's immune system to fight the …
News Release
Receiving a cancer diagnosis can feel like losing control of everything.
… an aggressive tumor - neither of which are ideal. … How tumors differ from each other - either in different organs or … to the patient's specific tumor. A massive new analysis of tumors, published online April 17 in Epigenetics & Chromatin, … ignored among other issues." Researchers have found that tumors with CIMP are linked to different outcomes for …
Profile
Dr. Joan Bailey-Wilson, who retired in September 2022, looks back on her 42-year career as a scientist and reflects on the rapid growth of the genomics field.
… cancer. We identified the first gene to cause carcinoid tumors in one family we studied. What was truly exciting was … the high-risk genetic variant, diagnose and remove their tumors at a very early stage, and thus save their lives.  It … predict individuals at very high risk of carcinoid tumors. As one of the first in her family to go to college, …
Genetic Disorders
WAGR syndrome is a genetic condition caused by a deletion of genes located on chromosome 11, often causing eye problems and increased risk of cancer in babies.
… the condition: (W)ilms' Tumor, the most common form of kidney cancer in children. (A)niridia, some or complete … of individuals who have WAGR syndrome develop a type of kidney cancer called Wilms' tumor. In the early stages of … Excessive food intake (polyphagia/hyperphagia). Chronic kidney failure, most often after age 12 years. Breathing …
Profile
Reflecting on his NIH career, Dr. Smith recounts his journey from researcher to program director in a conversation with NHGRI science writer Sonja Soo, Ph.D. He looks ahead to a retirement filled with traveling, spending time with friends and family, playing pickleball and brewing ale.
… for mapping disease genes and studied conditions such as kidney failure and diabetes. Some high points were performing … of the Apol1 gene region that is a major contributor to kidney disease in African Americans.  I also had the … genomics, admixture, HIV and AIDS, cardiovascular and kidney disease. I knew it was time to change, and I had been …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… the inhibitor developed significantly fewer metastatic tumors than control mice that had not been treated. Some …
Research Funding
Effort to accelerate understanding of the molecular basis of cancer using genome analysis technologies, including large-scale genome sequencing.
… of genetic drivers of thyroid cancer  (2014)  Rare kidney tumor provides insights on role of metabolic changes … across many cancer genomes: A perspective  (2013)  Kidney cancer progression linked to shifts in tumor … Reports First Results of Comprehensive Study of Brain Tumors  (2008)  The Cancer Genome Atlas Awards Funds for …
Fact Sheets
Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.
… of cancer, or to a failure of the immune system to destroy tumors. In a type of brain tumor called glioblastoma, doctors … that counteracts temozolomide. Glioblastoma patients whose tumors have such methylated genes are far more likely to … stomach cancer, colon cancer and the most common type of kidney cancer. In some other cancers, changes in the …
Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
Research Funding
The Multi-Omics for Health and Disease Consortium aims to advance the application of multi-omic technologies to study health and disease in ancestrally diverse populations.
… at the Intersections of Environment, Diabetes, and Kidney Disease: A Multi-Omics for Health and Disease Study … Ali Gharavi Columbia University Multi-Omics for Chronic Kidney Disease Disease Study Site Louise Laurent*, Kathryn …