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Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… of mice and examined regulatory DNA and gene activity in brain and other tissue. They found that more than 80 percent … parent, they found that expression in 95 genes in the brain depended more on being inherited from one parent than … unexpectedly discovered that for thousands of genes in the brain, there was a slightly greater expression of genes …
News Release
National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study may inform the development of treatments for hearing loss in humans.
Staff
Dr. Acosta is a board-certified pediatric neurologist with the NIH Undiagnosed Diseases Program's GM1 gene therapy trial.
… using interspecies comparisons of clinical outcomes and brain connectivity changes using r-fMRI techniques. As … our intervention using traditional and novel techniques in brain MRI- including structural, magnetic resonance … (NCT02461420); and the “Autoimmune Brain Disorders Program” lead by Dr. Gena Mooneyham at NIMH. …
News Release
NIH researchers have identified and tested a molecule that shows promise as a possible treatment for Gaucher disease and Parkinson's disease.
… to treat Gaucher disease have not been able to enter the brain and reach those neurons that are affected in the most … ) is the nation's leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce …
Staff
Diana Bianchi is an adjunct investigator in the Medical Genetics Branch at the National Human Genome Research Institute.
… of new fetal nerve cells, and lead to improvement in brain growth, all of which will ultimately improve brain function, learning and memory after birth. Noninvasive … syndrome causes functional alterations of the developing brain resulting from abnormalities of neurogenesis, neuronal …
Clinical Research
El Programa de Enfermedades no Diagnosticadas (UDP) proporcionar respuestas a los pacientes con afecciones misteriosas que han eludido el diagnóstico durante mucho tiempo.
… Last Resort WFTV-TV Orlando, FL March 8, 2012: Mysterious brain lesions send Pasco County man to National Institutes of …
News Release
NHGRI researchers are studying the link between Parkinson's disease, and a rare disorder, Gaucher disease, by cross-breeding mice with the disease mutations.
… and her colleagues are now studying samples from different brain regions of these new cross-bred mice to discover what … the most severe forms of Gaucher disease that affect the brain, she said. Last year, Dr. Sidransky and other …
News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… system and can cause abnormal eye movements, seizures and brain damage. Current treatments often involve enzyme … this infused form of the enzyme cannot cross into the brain and treat the symptoms of the disease that affect the …
News Release
Researchers recommend more rigorous clinical study of dietary management practices for patients with IEMs, which may result in reformulating some medical foods.
… people must consume a certain amount to support body and brain growth and function. As others have observed in … isoleucine. This might have untoward effects on growth and brain development. Further observational studies led by Dr. … block methionine and other amino acid transport into the brain, where they are needed for growth. The authors worked …
News Release
NIH researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be enhanced.
… human chromosome 21. How these 45 extra genes affect the brain and behavior of the previous Ts65Dn mice has not been … extra 45 genes in the previous mouse model were affecting brain development and contributed to more severe difficulties … are considerable effects of these extra genes on mouse brain development and behavior,” said Faycal Guedj, Ph.D., …