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News Release
National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study may inform the development of treatments for hearing loss in humans.
… Study shows the role of transcription factors in facilitating cell regeneration …  Brightfield … that can switch genes on and off, known as transcription factors. To properly identify which transcription factors were at play, the researchers first had to look at …
Explainer
Appropriate use of population descriptors in research is a critical scientific issue that is important for advancing genomic science and improving healthcare across human populations.
… often hides underlying biological, environmental or social factors that may contribute to health and disease. In … attention to the full spectrum of potential contributing factors, including genomic, biological or clinical traits; … perceived physical appearance (such as skin color), social factors and cultural backgrounds. 4 Race has been used to …
News Release
The Telomere-to-Telomere (T2T) Consortium has generated the first truly complete sequence of a human Y chromosome - the final human chromosome to be fully sequenced.
… New sequence reveals genomic factors in fertility, including sperm production. … An … genomic features with implications for fertility, such as factors in sperm production. The study, led by the … While these chromosomes play a central role, the factors involved in human sexual development are spread …
Event
The Advances in Genomic Technology Development (AGTD) 2022 Annual Meeting was hosted by the Technology Development Coordinating Center (TDCC) from July 12-14, 2022 at The Jackson Laboratory (Farmington, CT).
… for Highly Parallel Analysis of Variation in Transcription Factors and their DNA Binding Sites Shubham Khetan, … in situ Method to Study the Combinatorial Code of Epigenetic Marks in Single Cells Yanbo Chen Yale University … discussed genomic technologies that include nanopore and epigenetic sequencing as well as multi-omic analyses of …
Clinical Research
GENE-FORECAST® is developing a community cohort and resource for defining the significance of ancestry-related genomic variation in African-Americans.
… The Genomics, Environmental Factors and the Social Determinants of Cardiovascular Disease … and the exposome of social determinants and environmental factors that influence the pathogenesis of CVD in AA. The … common or ancestry-related DNA variants and CVD risk factors (e.g. hypertension) and phenotypes (e.g. coronary …
The Genomics Landscape
In the July 2023 edition of The Genomics Landscape, NHGRI Director Eric Green describes the evolution of the NHGRI Intramural Research program over the last three decades talks about its future in conducting truly exceptional basic, translational, and clinical genomics research.
… months.  All the best,   … Multifactorial profiling of epigenetic landscapes at single-cell resolution using … aiming to understand traits informed by many genetic factors and disease development.  This research was funded …
Clinical Research
The INSIGHTS study is exploring sickle cell disease in adults.
… exploring sickle cell disease in adults by looking at many factors, including genomic, microbial, physical and social … influences. … The goal of this study is to learn how these factors influence the onset and development of sickle cell … to sickle cell disease with a special emphasis on the factors that cause a subset of SCD patients to develop leg …
Diversity Center
Tuskegee University establishes the Carver Genomic Research Center.
… the key Xenobiotic alterations by transcriptomics, epigenetic and metabolomic profiling in Urothelial Carcinoma … Genomic study to characterize the role of genetic and epigenetic factors affecting the tumor phenotype of triple negative …
News Release
NHGRI researchers and colleagues are calling for health disparities research that focuses on the microbiome.
… be a two-way street, with the biological and environmental factors influencing each other, according to the perspective … the socioeconomic, psychosocial, cultural and behavioral factors in people of diverse ancestry, according to the … microbiome interacts with social and environmental factors," said Vence L. Bonham, Jr., J.D., perspective …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… response to perturbing agents - such as drugs and genetic factors - that are potentially disruptive to cells. LINCS … cellular model systems. Cellular phosphor-signaling and epigenetic systems are involved in a growing number of …