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National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in May 2024.
… Cell-Free DNA Screening in a Safety Net Setting" 26 Knockout Mouse Phenotyping Project (KOMP2) KOMP2 Program … Influence Mitochondrial Heteroplasmy Levels in Mice" 39 ‘One-Stop-Shop’ to Stay Connected … May 2024 … …
Staff
Cynthia Tifft, M.D., Ph.D. is the deputy clinical director for the National Human Genome Research Institute.
… could double the lifespan of Sandhoff disease mice, not by decreasing the storage of GM2 ganglioside, but …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2023.
… to Promote Diversity in Health-Related Research 33 Knockout Mouse Phenotyping Project (KOMP2) KOMP2 Website IMPC … of Leukemia Progression in the Cbfb-MYH11 Knockin Mice by Single Cell RNA Sequencing" Turriff et al. – …
Staff
Sheethal Jose is a program director in NHGRI's Division of Genomics and Society.
… Medical Records and Genomics (eMERGE) Network and the Knockout Mouse Program (KOMP)/International Mouse Phenotyping …
Staff
Dr. Shawn Burgess is the co-deputy director of NHGRI's Intramural Research Program.
… last decade has been focused on developing efficient gene knockout technologies in zebrafish, coupled with efficient … M, Burgess SM, Lin S. A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. …
The Genomics Landscape
In the January 2024 issue of The Genomics Landscape, NHGRI Director Eric Green announces the appointment of Dr. Adam Phillippy as the founding director of the Center for Genomics and Data Science Research (CGDSR).
… the cellular receptor for SARS-CoV-2. In the edited mice, expression patterns of ACE2 were similar to those in …
News Release
A new study offers insights into why some people's hair goes gray in response to a serious illness or chronic stress.
… Decreasing the expression of the MITF gene in the mutant mice increased the interferon signature in melanocyte stem … of melanocytes. Overexpression of SOX10 in these mice caused hair graying. Combining the two mouse models by mating the mice produced greater amounts of gray hair. This combined …
News Release
Research points to the effects of nutrients in how DNA mutates in the mitochondria.
… life.” The researchers first searched for mutations in mice that were bred to be genetically identical. That way, … that were already present. “You could think of all the mice we studied as being large groups of identical twins,” … “The traits and characteristics we were looking at in the mice reflect a combination of genes and environment, so in …
Research Funding
NHGRI's programs and projects support research in one of six domains to advance the field of genomics and improve human health.
… Project Implementing Genomics into Practice (IGNITE) Knockout Mouse Program (KOMP) Large-Scale Genome Sequencing …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… Hill, and his colleagues crossbred several strains of mice and examined regulatory DNA and gene activity in brain … variation and parental influence on gene activity in mice and humans, as well as the cause of complex traits and … NHGRI, NIMH, and NIGMS are parts of NIH. lllustration of mice of different colors surrounded by a DNA double helix. …