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- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
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Fact Sheet
Learn about the different types of hemoglobin.
… and gene therapy , you should first know about blood cells and the different types of hemoglobin that make up red … which causes different health complications. … Blood stem cells (also called hematopoietic stem cells) are cells that can develop into any type of blood …
Educational Resources
Sickle cell disease is a hereditary disease seen most often among people of African ancestry.
… recessive trait. The mutation causes the red blood cells to take on an unusual sickle shape. Individuals …
Staff
Lisa Garrett is an associate investigator and director of the NHGRI Transgenic Mouse Core.
… is a staff scientist and director of the NHGRI Transgenic Mouse Core at the NIH. In 1984, she received her M.S. at … In 1994, Ms. Garrett began as a supervisor in the NHGRI Embryonic Stem Cell and Transgenic Mouse Core and became director in …
News Release
NIH researchers and collaborators have found that that sickle cell trait is prevalent among diverse human populations.
… cell disease, a genetic condition that causes red blood cells to become rigid and sticky, which blocks blood flow. …
Educational Resources
Apoptosis is the process of programmed cell death.
… It is used during early development to eliminate unwanted cells; for example, those between the fingers of a developing … hand. In adults, apoptosis is used to rid the body of cells that have been damaged beyond repair. Apoptosis also …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… contains the instructions needed to build and maintain cells. These instructions are spelled out in the form of … the world-the Mammalian Gene Collection initiative and the Mouse Transcriptome Project. The Mammalian Gene Collection … initiative built a free, public library of human, mouse, and rat mRNA sequences. The project was led by NHGRI …
Staff
Dr. Paul Liu is a senior investigator in NHGRI's Translational and Functional Genomics Branch.
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… gene CBFB - MYH11, Dr. Liu's group generated a knock-in mouse model, which demonstrated that CBFB - MYH11 blocks … mouse models. The zebrafish is a useful model for studying embryonic development and is easily amenable to large-scale … made novel findings regarding its role in hematopoietic stem cell production (Bresciani, Blood in press). Overall the …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) aims to identify all functional elements in the human and mouse genomes.
… Mapping of Long-Range Chromatin Interactions in Human and Mouse Genomes UM1 HG009409 Michael Snyder Stanford University … University of California, Irvine High Precision Human and Mouse Transcriptomes UM1 HG009443 Functional Characterization … … As the ENCODE Project has increased its study of primary cells and tissues, it has begun working on human biological …
Educational Resources
The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes.