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Dr. David Bodine is the chief of and senior investigator in NHGRI's Genetics and Molecular Biology Branch.
… genome, including epigenetic marks and sites occupied by transcription factors, primarily focusing on cell lines or … state (chromatin accessibility, histone modifications, transcription factor binding, DNA methylation and 3D … stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites. Genome Res , …
The Genomics Landscape
In the November 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, celebrates the 30th anniversary of the NHGRI Intramural Research Program as well as announces the launch of a new digital history archive.
… and humans. The researchers identified multiple transcription factors — proteins that regulate the expression …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
Research at NHGRI
The Genetic Disease Research Branch studies how genetic changes affect the structure and function of gene products leading to human disease.
… in understanding how disruptions in signaling pathways and transcription factors contribute to disease. Our …
News Release
Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.
… of protein that helps turn genes on and off, known as a transcription factor. The STAT4 protein not only plays a role …
Educational Resources
Messenger RNA (abbreviated mRNA) is a type of single-stranded RNA involved in protein synthesis.
… mRNA is made from a DNA template during the process of transcription. The role of mRNA is to carry protein …
Research at NHGRI
The Metabolic Medicine Branch houses clinical and laboratory research programs that focus on the development of new therapies for patients with genetic disorders.
The Genomics Landscape
In the July 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes the inaugural class of the ASHG-NHGRI Genomics and Public Service Fellowship Program.
… gene expression noise. They also found that the binding of transcription factors, proteins critically involved in the …