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Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… Hill, and his colleagues crossbred several strains of mice and examined regulatory DNA and gene activity in brain … variation and parental influence on gene activity in mice and humans, as well as the cause of complex traits and … NHGRI, NIMH, and NIGMS are parts of NIH. lllustration of mice of different colors surrounded by a DNA double helix. …
News Release
Using a recently developed DNA base-editing technique, researchers correct accelerating aging disorder.
… used a DNA-editing technique to extend the lifespan of mice with the genetic variation associated with progeria, a … this mutation might affect progeria-like symptoms in mice. "The toll of this devastating illness on affected … injection of the DNA-editing mix into nearly a dozen mice with the progeria-causing mutation soon after birth. The …
Research Funding
The Knockout Mouse Phenotyping Project (KOMP2) collaborates with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome.
… the mouse genome. … Humans share most of their genes with mice. Because of this, the laboratory mouse has served as a … can then observe the characteristics of knockout mice to obtain information to help researchers better … comprehensive and public resource comprised of null mutant mice and their phenotype information. As part of the …
Staff
Dr. Manoli is a pediatrician, clinical and biochemical geneticist in the Organic Acid Research Section of the Metabolic Medicine Branch at NHGRI.
… cold exposure or fasting in liver- and muscle-specific transgenic MMA mice and modeled clinically relevant disease manifestations, …
News Release
NIH researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be enhanced.
… mouse model. Scientists often use different strains of mice as animal models to study human diseases because most genes in humans have similar counterparts in mice. “A mouse model that more precisely captures the … a byproduct of how the model was developed. Humans and mice have very similar genomes, but the chromosomes that make …
Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
… promise.   Researchers used bioengineering to create mice with a human gene that produces the defective hemoglobin … the defective hemoglobin gene was removed from the mice and genetically "corrected" by the addition of the … The corrected marrow was then transplanted into other mice with sickle cell disease. The genetically corrected mice …
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
… of different model organisms are used in this regard, but mice are especially useful because they share mammalian …
News Release
NHGRI researchers identified 59 genes or gene regions linked to canine athletics.
… muscle endurance by reducing pain. In a previous study in mice, researchers discovered that the ASIC3 gene is linked to … gene, which have been linked to hearing impairment in mice and humans, were significantly more common in sport … behaviors, hyperactivity and panic responses in mice ( SHANK2 and OXR1 genes) were also more prevalent in …
News Release
The Encyclopedia of DNA Elements (ENCODE) Project has created a detailed resource on the letters of life, DNA, identifying genes and regions that may regulate genes in the human and mouse genomes.
… nearly 6,000 experiments –– 4,834 in humans and 1,158 in mice –– to illuminate details of the genes and their … biochemical changes that occur during mouse development. Mice, due to their genomic and biological similarity to … human biology and disease. These experiments in humans and mice were carried out in several biological contexts. …
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… this hypothesis, the researchers genetically engineered mice with FMF-causing genomic variants. They infected both healthy and genetically engineered mice with Yersinia pestis . Their results showed that infected mice with the FMF-causing genomic variant had significantly …