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News Release
NHGRI researchers have released new educational materials to help the sickle cell disease community learn about gene therapies for the disease.
… their support networks navigate emerging developments in gene therapies for sickle cell disease. … New educational … to help the sickle cell disease community learn about gene therapies for the disease are now available from … The Democratizing Education for Sickle Cell Disease Gene Therapy Project, led by Vence Bonham Jr., J.D., NHGRI acting …
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… genome-editing research. … In light of recent advances in gene-editing research and technologies, the National … decision making for the responsible use of human gene-editing research. This initiative examined the clinical, … of gene editing, germline modifications, somatic cell therapy, societal implications, international perspectives, …
News Release
An expert panel from the Clinical Genome Resource (ClinGen) has critically reevaluated the scientific evidence for all 17 reported genes, disputing nine of the genes and revealing only three of the genes to be definitively associated with the most common form of the disease.
… ClinGen panel also validates three genes believed to be associated with long QT syndrome … Geneticists and heart … and revealing only three of the genes to be definitively associated with the most common form of the disease. The work … reporting to physicians. Published papers reporting gene-disease associations vary widely in their study design …
News Release
Researchers funded by NIH have completed a detailed atlas documenting stretches of human DNA that influence gene expression.
… documenting the stretches of human DNA that influence gene expression - a key way in which a person's genome gives … scale used by GTEx that enabled researchers to study how gene expression in the liver might be different than in the … are identified by establishing which specific variants are associated with differences in gene expression levels. The …
Educational Resources
Nucleic acids are large biomolecules that play essential roles in all cells and viruses.
… … Nucleotide, Genetic Code, DNA, Deoxyribonucleic Acid, Gene Expression … Nucleic acids are large biomolecules that …
News Release
NIH researchers have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The study, led by scientists at the National Human Genome Research Institute (NHGRI), found that individuals diagnosed with ADHD had differences in genes that code for known chemicals that brain cells use to communicate.
… Health (NIH) have successfully identified differences in gene activity in the brains of people with attention deficit … gene expression . They studied two connected brain regions associated with ADHD: the caudate and the frontal cortex. … advances, researchers have been able to identify genes associated with ADHD, but they had not been able to determine …
Virtual Exhibit
The Gene Sweepstakes — or GeneSweep as it became popularly known — was a three-year-long, sweepstakes-style contest organized by British bioinformatician Ewan Birney, Ph.D., of the European Bioinformatics Institute. Scientists participated in the contest by betting on the total number of protein-coding genes that would be identified in the human genome sequence generated by the Human Genome Project.
… director at the time, included a section dedicated to the “Gene Sweepstake,” pointing out that the basis of GeneSweep … (left) and the GeneSweep page document located behind associated Tab I. (From NHGRI History of Genomics Archive). … … … In April 2003, after more than 460 predictions and their associated wagers have been made, the Human Genome Project …
Community Outreach
NHGRI is proud to help support the PBS documentary, “Ken Burns presents The Gene: An Intimate History,” based on the book by Siddhartha Mukherjee, M.D.
… help support the PBS documentary, “Ken Burns presents The Gene: An Intimate History,” based on the book by Siddhartha Mukherjee, M.D. The Gene aired April 7 and 14 at 8:00 p.m. ET. The series, based … the history of science. … In this fun animated series, the gene’s complex mechanisms are explored in simple ways. … …
News Release
As researchers uncover millions of DNA differences in genes, doctors struggle to know which of these inherited differences, called variants, really matter.
… of lab results with uncertain findings about whether a gene or variant is disease-causing," said Jonathan Berg, … basic questions: Is there a true relationship between a gene and disease? Does the genetic variant in a gene cause or contribute to disease? For a person who has one …
Fact Sheet
Viruses are bundles of genetic material wrapped in a protein coat that can infect living things.
… as being bitten by a mosquito infected with the West Nile virus. When viruses (and other pathogens) move from one … lock. When the key meets the lock, it opens a door for the virus to enter the cell. Viruses enter host cells as … being capable of infecting another cell. Once a virus successfully replicates itself, it leaves the host cell …