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Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.
… analyze and interpret DNA sequence information from cancer patients. They have developed an algorithm that sorts … to their clinical and biological relevance to a patient's cancer. … The findings eventually may help guide … Human Genome Research Institute (NHGRI), and the National Cancer Institute, both part of the National Institutes of …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted … an association between AAV and the occurrence of liver cancer. The present research addresses this problem in gene … documented a 50-70 percent higher occurrence of liver cancer in AAV-treated mice compared with a 10 percent liver …
Media Availability
TCGA researchers have found that chromophobe renal cell carcinoma stems partly from gene alterations in the mitochondria, the cell's energy supplier.
… Steven Benowitz … Media Availability Researchers in The Cancer Genome Atlas (TCGA) Network have made a number of new … about the biology and development of a rare form of kidney cancer. … They found that the disease - chromophobe renal … of the 66 ChRCC tumors studied, a high number for a rare cancer. The study revealed increased numbers of mitochondria …
Staff
Dr. Settara Chandrasekharappa is an associate investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… genomic research for NHGRI investigators. As head of the Cancer Genomics Unit, his research efforts led to the … to study the molecular pathogenesis in FA. … The Cancer Genomics Unit (CGU) focuses on adopting genomic … in search of the gene responsible for early onset breast cancer ( BRCA1 ), CGU developed resources and aided in the …
Staff
Dr. Paul Meltzer is an adjunct investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… is a leader in the application of genome science to cancer research. His recent studies investigate the genetic … Asian Hepatocellular Carcinoma and Cholangiocarcinoma . Cancer Cell , 32(1):57-70.e3. 2017. Killian JK, Dorssers LC, … osteosarcoma profiling, melanoma profiling, breast cancer profiling, technology development … Paul Meltzer, …
Genetic Disorders
Klinefelter syndrome is a condition that occurs in men as a result of an extra X chromosome. The most common symptom is infertility.
… syndrome is associated with an increased risk for breast cancer, a rare tumor called extragonadal germ cell tumor, lung disease, varicose veins and osteoporosis. Men who have … Gynecomastia, Breast Cancer, Extragonadal Germ Cell Tumor, Lung Disease, Varicose Veins, Osteoporosis, Lupus, Rheumatoid …
Staff
Dr. Heidi Parker is an Associate Investigator in the Comparative Genetics Section of the Cancer Genetics and Comparative Genomics Branch, NHGRI.
… Investigator in the Comparative Genetics Section of the Cancer Genetics and Comparative Genomics Branch at the … laboratory of Dr. Elaine Ostrander at the Fred Hutchinson Cancer Research Center, established the first classification … genomic loci involved in complex morphological traits and cancer susceptibility. Dr. Parker has capitalized on the …
… Cáncer de próstata … Prostate cancer is a disease characterized by uncontrolled cell growth … which is part of the male reproductive system. Prostate cancer generally affects men over the age of 50. It is … for more deaths among men than any other cancer except lung cancer. …
Talking Glossary
Un carcinógeno es una sustancia, organismo o agente capaz de causar cáncer.
… is a substance, organism or agent capable of causing cancer. Carcinogens may occur naturally in the environment …
Talking Glossary
BRCA1 y BRCA2 son los dos primeros genes que se identificaron como asociados a tipos hereditarios del cáncer de mama y de ovario. Las personas con mutaciones en BRCA1 o BRCA2 tienen un riesgo mucho más alto de desarrollar cáncer de mama, de ovario u otros tipos de cáncer en comparación con las personas que no tienen mutaciones en estos genes.
… found to be associated with inherited forms of breast cancer and ovarian cancer. People with mutations in either BRCA1 or BRCA2 have a … risk for developing breast, ovarian or other types of cancer than those without mutations in the genes. Both BRCA1 …