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News
To prevent an emerging genomic technology from contributing to health disparities, a scientific team funded by the National Institutes of Health has devised new ways to improve a genetic testing method called a polygenic risk score.
… polygenic risk scores have not been effective for all populations, the researchers recalibrated these genetic tests … calculate the scores often heavily overrepresent people of European ancestry. “Recently, more and more studies … represented about three times as many individuals of non-European ancestry compared to other major datasets …
Research Funding
The IGNITE PTN supports a network of multi-site clinical groups involving diverse settings and populations to conduct two pragmatic clinical trials of genomic medicine interventions.
… The Implementing Genomic in Practice (IGNITE) Network was established in 2013 ( RFA-HG-12-006 ,  RFA-HG-12-007  and  RFA-HG-13-004 ) to develop methods for incorporating … Coordinating Center (CC) involving diverse settings and populations to conduct pragmatic clinical trials of genomic
News Release
An international team of researchers including NIH has completed the first comprehensive characterization of genomic diversity across sub-Saharan Africa.
… unique. "The rich genomic diversity in sub-Saharan African populations can offer new insights about disease … genetic variant frequency in populations from endemic and non-endemic regions suggests that this effect may be in … have been conducted that include populations with mainly European ancestry." The GWAS approach involves rapidly …
The Genomics Landscape
In the June 2020 edition of The Genomics Landscape, NHGRI Director Eric Green details NHGRI's new Diversity in Genomics Workforce Initiative.
… across the United States on top of the illness, death, and physical isolation that we have been experiencing … on increasing the diversity of the next generation of genomic researchers. The NHGRI Diversity Action Plan (DAP) … diversity ” of the workforce encompasses underrepresented populations in the U.S. biomedical, clinical, behavioral, and
Diversity Center
The Pacific Center for Genome Research (PCGR) at the University of Hawaii at Manoa (UHM) aims to grow and support Genomic Research workforce at UHM, a Minority Serving Institution (MSI), which has a mission to serve historically underrepresented population in biomedical research, namely, Native Hawaiians and other Pacific Islanders.
… at the University of Hawaii at Manoa (UHM) aims to grow and support Genomic Research workforce at UHM, a Minority … programs. Cultivate community engagement with the diverse populations of Hawai‘i and integrate genomics research with …   Integrating genome, other layers of omics, and non-genetic data to improve understanding of the etiology of …
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… Prabarna Ganguly, Ph.D. … Genomic variants that cause common periodic fever have spread in Mediterranean populations over centuries, potentially protecting people … research was provided by the National Institute of Allergy and Infectious Diseases, the National Institute of Arthritis …
Genomics and Medicine
The NHGRI Genomic Medicine Working Group has compiled a list of interesting advances.
… The NHGRI Genomic Medicine Working Group  (GMWG) compiles a list of interesting advances and helpful educational resources in genomic medicine. To … for specific publications by title, author, category and/or by date range.  For an explanation about the selection …
The Genomics Landscape
In the July 2020 edition of The Genomics Landscape, NHGRI Director Eric Green recalls the White House event announcing the draft human genome sequence.
… is likely the case for many of your organizations, NHGRI and NIH are starting to bring some of our staff back to the … (ACMG) recently published guidance on incorporating genomic data into electronic health records (EHRs). EHRs are … on COVID-19 testing among underserved and/or vulnerable populations Emergency competitive revisions for …
The Genomics Landscape
In the October 1, 2020 edition of The Genomics Landscape, Dr. Eric Green reflects on the last 30 years since the launch of the Human Genome Project.
… with the Human Genome Project successfully completed and genomics maturing into a well-respected discipline. I am … not an endeavor for a serious postdoctoral research fellow and that genomics was not a field with a bright future! But … describes the largest and most comprehensive catalog of genomic variants that affect gene expression produced to …
The Genomics Landscape
In the June 2018 issue of The Genomics Landscape, NHGRI Director Eric Green highlights the success of The Cancer Genome Atlas.
… used a variety of techniques to analyze the tumor and non-tumor samples, including exome and whole-genome … Genes Revealed Genomic Databases Weakened by Lack of Non-European Populations NIH-Funded Researchers Identify Target for …