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- Ethical, Legal and Social Implications (ELSI) Research Program6
- Genomics-Enabled Learning Health Systems (gLHS)2
- Genetic Architecture of Complex Traits1
- Genome Technology Program5
- Human Genome Reference Program (HGRP)2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Encyclopedia of DNA Elements (ENCODE) Project1
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- Genomic Innovator Awards2
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)3
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
- Developmental Genotype-Tissue Expression (dGTEx)1
- Multi-Omics for Health and Disease (Multi-Omics)1
News
To prevent an emerging genomic technology from contributing to health disparities, a scientific team funded by the National Institutes of Health has devised new ways to improve a genetic testing method called a polygenic risk score.
… polygenic risk scores have not been effective for all populations, the researchers recalibrated these genetic tests … calculate the scores often heavily overrepresent people of European ancestry. “Recently, more and more studies … represented about three times as many individuals of non-European ancestry compared to other major datasets …
Research Funding
The IGNITE PTN supports a network of multi-site clinical groups involving diverse settings and populations to conduct two pragmatic clinical trials of genomic medicine interventions.
… The Implementing Genomic in Practice (IGNITE) Network was established in 2013 ( RFA-HG-12-006 , RFA-HG-12-007 and RFA-HG-13-004 ) to develop methods for incorporating … Coordinating Center (CC) involving diverse settings and populations to conduct pragmatic clinical trials of genomic …
News Release
An international team of researchers including NIH has completed the first comprehensive characterization of genomic diversity across sub-Saharan Africa.
… unique. "The rich genomic diversity in sub-Saharan African populations can offer new insights about disease … genetic variant frequency in populations from endemic and non-endemic regions suggests that this effect may be in … have been conducted that include populations with mainly European ancestry." The GWAS approach involves rapidly …
The Genomics Landscape
In the June 2020 edition of The Genomics Landscape, NHGRI Director Eric Green details NHGRI's new Diversity in Genomics Workforce Initiative.
… across the United States on top of the illness, death, and physical isolation that we have been experiencing … on increasing the diversity of the next generation of genomic researchers. The NHGRI Diversity Action Plan (DAP) … diversity ” of the workforce encompasses underrepresented populations in the U.S. biomedical, clinical, behavioral, and …
Diversity Center
The Pacific Center for Genome Research (PCGR) at the University of Hawaii at Manoa (UHM) aims to grow and support Genomic Research workforce at UHM, a Minority Serving Institution (MSI), which has a mission to serve historically underrepresented population in biomedical research, namely, Native Hawaiians and other Pacific Islanders.
… at the University of Hawaii at Manoa (UHM) aims to grow and support Genomic Research workforce at UHM, a Minority … programs. Cultivate community engagement with the diverse populations of Hawai‘i and integrate genomics research with … Integrating genome, other layers of omics, and non-genetic data to improve understanding of the etiology of …
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… Prabarna Ganguly, Ph.D. … Genomic variants that cause common periodic fever have spread in Mediterranean populations over centuries, potentially protecting people … research was provided by the National Institute of Allergy and Infectious Diseases, the National Institute of Arthritis …
Genomics and Medicine
The NHGRI Genomic Medicine Working Group has compiled a list of interesting advances.
… The NHGRI Genomic Medicine Working Group (GMWG) compiles a list of interesting advances and helpful educational resources in genomic medicine. To … for specific publications by title, author, category and/or by date range. For an explanation about the selection …
The Genomics Landscape
In the July 2020 edition of The Genomics Landscape, NHGRI Director Eric Green recalls the White House event announcing the draft human genome sequence.
… is likely the case for many of your organizations, NHGRI and NIH are starting to bring some of our staff back to the … (ACMG) recently published guidance on incorporating genomic data into electronic health records (EHRs). EHRs are … on COVID-19 testing among underserved and/or vulnerable populations Emergency competitive revisions for …
The Genomics Landscape
In the October 1, 2020 edition of The Genomics Landscape, Dr. Eric Green reflects on the last 30 years since the launch of the Human Genome Project.
… with the Human Genome Project successfully completed and genomics maturing into a well-respected discipline. I am … not an endeavor for a serious postdoctoral research fellow and that genomics was not a field with a bright future! But … describes the largest and most comprehensive catalog of genomic variants that affect gene expression produced to …
The Genomics Landscape
In the June 2018 issue of The Genomics Landscape, NHGRI Director Eric Green highlights the success of The Cancer Genome Atlas.
… used a variety of techniques to analyze the tumor and non-tumor samples, including exome and whole-genome … Genes Revealed Genomic Databases Weakened by Lack of Non-European Populations NIH-Funded Researchers Identify Target for …