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- Genome Technology Program5
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Educational Resources
An open reading frame is a portion of a DNA molecule that, when translated into amino acids, contains no stop codons.
… Mutation, Amino Acids, Base Pair, Codon, Deoxyribonucleic Acid (DNA) … An open reading frame, as related to genomics, … a unit of genomic information encoding a particular amino acid or signaling the termination of protein synthesis (stop … often part of a gene (that is, a sequence directly coding for a protein). … An open reading frame is a portion of a DNA …
Educational Resources
The nucleopore is one of a series of small holes found in the nuclear membrane.
… holes found in the nuclear membrane. … Nuclear Membrane, Nucleic Acid, Cell, Nucleus, Protein … A nucleopore is one of a … the cell’s nuclear membrane. Nucleopores serve as channels for the selective transport of nucleic acids and proteins …
News Release
Ten investigators will receive exome sequencing data as part of their clinical research projects at the NIH Clinical Center.
… Kaegi … Ten intramural investigators will receive exome sequencing data as part of their clinical research projects … Genome Research Institute (NHGRI), the NIH Deputy Director for Intramural Research, and the NIH Clinical Center. Using … use exome sequencing data from 100 patients to identify novel cancer susceptibility genes in kidney cancer patients. …
For Teachers
A microbiome is all of the genetic material found in a microbe, such as a bacterium, fungal cell or virus.
… found in a community of microbes. … Teacher's resources for teaching about microbes and the microbiome A teacher's tools website with resources for use in biology classes … Friends and the Symbiosis Scramble Microbiome learning tools for students Student or family-oriented learning …
News Release
A new study by researchers at the National Human Genome Research Institute (NHGRI) is challenging traditional practices for validating DNA sequencing results.
… Institute (NHGRI) is challenging traditional practices for validating DNA sequencing results. The research suggests that newer, faster, … NGS results. The study may have important implications for the DNA sequencing of clinical samples, and perhaps …
News Release
NIH lost a key member of its broader genomics team when Robert Blakesley, Ph.D., director of the NISC sequencing group at NIH, retired on Dec. 31, 2015.
… NISC generated more than 57 million DNA sequence reads for 76 researchers using the Sanger dideoxy sequencing … "My father was always figuring something out, making new tools or building electronic devices. I absorbed his desire … of polymerases (enzymes that make long chains of nucleic acids, such as DNA and RNA). Recruited by Bethesda …
Talking Glossary
Nanopore DNA sequencing is a laboratory technique for determining the exact sequence of nucleotides, or bases, in a DNA molecule.
… Nanopore DNA Sequencing … Nanopore DNA sequencing is a laboratory technique for determining the exact sequence of nucleotides, or bases, … … Nanopore DNA sequencing is a laboratory technique for determining the exact sequence of nucleotides, or bases, …
Talking Glossary
The genome reference sequence provides a general framework and is not the DNA sequence of a single person.
… genome sequence that is used by researchers as a standard for comparison to DNA sequences generated in their studies. The scientists responsible for assembling and updating such reference sequences aim to …
Research at NHGRI
The NIH Intramural Sequencing Center is a multi-disciplinary genomics facility that emphasizes the generation and analysis of DNA sequence.
… The NIH Intramural Sequencing Center (NISC) , established in 1997, is a … (NIH) access to well established, high-throughput DNA sequencing, NISC works closely with NIH collaborators to … across the NHGRI Intramural Research Program to develop novel methods to analyze genomics data with applicability to …
Fact Sheets
A DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes.
… large genes have many regions where mutations can occur. For example, researchers believe that mutations in the genes … But there is not one specific mutation responsible for all of these cases. Researchers have already discovered … related to those drugs.With the advent of new DNA sequencing technologies, some of the tests for which …