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Talking Glossary
Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of proteins that the gene encodes.
… … Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more … … Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more … … Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more …
Educational Resources
A bacterial artificial chromosome (BAC) is an engineered DNA molecule used to clone DNA sequences in bacterial cells (for example, E. coli).
Educational Resources
A Golgi body, also known as a Golgi apparatus, is a cell organelle that helps process and package proteins and lipid molecules, especially proteins destined to be exported from the cell.
… that helps process and package proteins and lipid molecules, especially proteins destined to be exported from … that helps process and package proteins and lipid molecules, especially proteins destined to be exported from … that helps process and package proteins and lipid molecules, especially proteins destined to be exported from …
Educational Resources
Hybridization is the process of combining two complementary single-stranded DNA or RNA molecules and allowing them to form a single double-stranded molecule through base pairing.
… of combining two complementary single-stranded DNA or RNA molecules and allowing them to form a single double-stranded … in which two complementary single-stranded DNA and/or RNA molecules bond together to form a double-stranded molecule. … appropriate base-pairing across the two single-stranded molecules. Hybridization is an important process in various …
Educational Resources
A phosphate backbone is the portion of the DNA double helix that provides structural support to the molecule.
Educational Resources
Yeast artificial chromosome (YAC) is a human-engineered DNA molecule used to clone DNA sequences in yeast cells.
Event
A joint NHGRI-NCATS hosted meeting bringing together researchers, clinicians, families and patient advocates from around the world to discuss the natural history, disease pathophysiology, genetics and treatments for rare inborn metabolic errors.
… M.D. 2:50 - 3:10 p.m. Hepatocyte-Based Models and Small Molecule Therapies for MMA/PA Kimberly A. Chapman, … clinical and scientific partners to develop genomic and small molecule therapies for a number of the enzymatic … patients and their physicians face in several upcoming small molecule, enzyme replacement and genomic phase I/II …
The Genomics Landscape
In the January 5, 2023 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., talks about how artificial intelligence and machine learning are becoming omnipresent throughout NHGRI and in genomics.
… (e.g., chemically processing or breaking down) molecules such as carbohydrates, fats, medications, and even … DNA, however, is not identical among all people, and the small differences among human genomes (i.e., genomic … through the cloud-based All of Us Researcher Workbench . Small grants to enhance the use of the All of Us Research …
Fact Sheet
Genomic variation accounts for some of the differences among people, including important aspects of their health and susceptibility to diseases.
… multiple types of variants in human genomes, ranging from small differences to large differences.  A very small subset of genomic variants contributes to human health … influence on the functioning of a person’s genome, but a small subset of variants do have an impact. For example, some …
Fact Sheet
Viruses are bundles of genetic material wrapped in a protein coat that can infect living things.
… between living and nonliving organisms. They are so small (a millionth of a millimeter) that it would take … that infect plants and animals also have a layer of fat molecules. Viruses cannot reproduce on their own. Instead, … immune system responds. When injected, these DNA or RNA molecules are used by the host to produce specific viral …