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News Release
Daniel Kastner, M.D., Ph.D., Scientific Director for the Intramural Research Program at the National Human Genome Research Institute (NHGRI) recognized for his pioneering work on the genomics of autoinflammatory diseases.
… inflammation and tissue damage, affecting the nervous system, skin and joints. Affected individuals can eventually … a separate branch of immunity called the innate immune system. Therefore, it became clear that autoinflammatory …
Explainer
Appropriate use of population descriptors in research is a critical scientific issue that is important for advancing genomic science and improving healthcare across human populations.
… used to inappropriately group people into a hierarchical system to "establish and justify systems of power, privilege, … . Race has been used to group people into a hierarchical system that identifies, distinguishes and marginalizes some …
Research at NHGRI
The Genetic Disease Research Branch studies how genetic changes affect the structure and function of gene products leading to human disease.
… human diseases, particularly those affecting the nervous, immune and musculoskeletal systems. As a major emphasis of …
The Genomics Landscape
In the October 2018 edition of The Genomics Landscape, NHGRI Director Dr. Eric Green highlights Dr. Dan Kastner as the Federal Employee of the Year.
… illnesses, proposed a now widely-accepted explanation for immune disorders, identified critical insights into innate … include discovering new molecules in the human innate immune system and providing important insights into their function; …
FAQ
Addressing the COVID-19 pandemic and what it means to the pediatric mitochondrial disease community.
… disease. We evaluate their infection risk and immune function, and we document any complications that …
News Release
NHGRI researchers have discovered clues to the possible cause of recurring, non-contagious fevers and sores that affect only children. Several genes have been implicated with the syndrome, known as PFAPA syndrome (Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis), which could lead to new treatments.
… an inflammation-related protein that is used by the immune system. The IL12A protein acts as an alarm for the immune system and prompts an inflammatory response by …
News Release
NHGRI researchers and colleagues are calling for health disparities research that focuses on the microbiome.
… habits and sleep patterns. Stress, its impact on the immune system and its role on disease risk is another important area … that the microbiome may change in response to the immune system and vice versa. In response, they propose a …
Policy Issues
Genetic information is used by law enforcement to investigate criminal acts and exonerate those who have been convicted of crimes they did not commit.
… by law enforcement to investigate criminal acts. The legal system also uses genetic information to exonerate those who … with respect to privacy. … The Combined DNA Index System (CODIS) is the Federal Bureau of Investigation’s (FBI) … on investigative genetic genealogy. … Combined DNA Index System (CODIS) … Investigative Genetic Genealogy (IGG) … …
Policies and Guidance
NHGRI does not collect personally identifiable information about you on genome.gov unless you volunteer to provide it.
… assigned to a computer when surfing the Web); Operating system and information about the browser used when visiting … If we store your personal information in a record system designed to retrieve information about you by personal …
15 Ways Genomics Influences Our World
Genomics is altering a genome with unparalleled efficiency and precision.
… CRISPR recognized that they could borrow tools from the immune system of bacteria  and develop "bacterial scissors" for … Then, it makes copies of itself to infect the person's immune system, making them vulnerable to other infections. …