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Elaine Ostrander is chief of NHGRI's Cancer Genetics and Comparative Genomics Branch.
… the utility of dogs for cancer genetics by mapping kidney cystadeno-carcinoma in German Shepherds, prior to its … of the bladder 27, 28 , and canine transmissible venereal tumors 29 . Prostate Cancer : We have worked for the last … landscape of BRCA2-associated aggressive prostate tumors, defining a signature of an increased somatic mutation …
Event
The Genomics and Health Disparities Lecture Series was formed to enhance opportunities for dialogue about how innovations in genomics research and technology can impact health disparities. Topics will range from basic science to translational research.
… National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute on Minority Health …
Research at NHGRI
CRGGH facilitates understanding of the relationship between genetic variation and population differences in disease distribution to inform health disparities.
… obesity, hypertension, diabetes, dyslipidemia, and kidney diseases, in different human populations with …
Diversity Center
Tuskegee University establishes the Carver Genomic Research Center.
… tumor microenvironment or immune contexture of the tumors However, many cancer patients do not participate in …
News Release
Investigators with The Cancer Genome Atlas Research Network have identified new potential therapeutic targets for a major form of bladder cancer.
… (which is commonly affected in cancers) in 44 percent of tumors. TP53 makes the p53 tumor suppressor protein, which … identified potential drug targets in 69 percent of the tumors evaluated. They found frequent mutations in the ERBB2 … responsible for cervical cancer - was found in bladder tumors. This suggests that viral infection can contribute to …
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… somatic mutations in PI3-kinase in endometrial tumors, thus uncovering previously unrecognized cohorts of … alterations that drive clinically aggressive endometrial tumors, and to understand their functional consequences. Dr. … the genetic and genomic alterations that drive solid tumors. In her previous position at Massachusetts General …
News Release
A new phase of the IGNITE Network will conduct clinical trials of genomic medicine interventions.
… treatment of high blood pressure, hypertension and chronic kidney disease. Both hypertension and high blood pressure exacerbate end-stage kidney diseases, and all three conditions are more common … L1 ( APOL1 ) gene that increase susceptibility to severe kidney disease by a factor of 10. Researchers will compare …
Educational Resources
Sickle cell disease is a hereditary disease seen most often among people of African ancestry.
News Release
The TCGA network describes uterine and bile duct cancer.
… uncontrolled cell growth that is the hallmark of malignant tumors. Last month, two publications from the TCGA network …