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The Genomics Landscape
NHGRI medical genetics training programs provide an array of education opportunities
… Equity Fellowship Program in partnership with the Food and Drug Administration’s (FDA’s) Office of Minority Health and … medical product development processes that facilitate the delivery of drugs, biologics, and devices from the bench to …
Research Funding
The three research domains to be considered for support by the NHGRI Ethical, Legal and Social Implications Research Program.
… the complex issues involved in ensuring the equitable delivery of genomic medicine to avoid exacerbating and to … of care providers’ implicit and unconscious biases on the delivery and uptake of genomic medicine. Genomic Information … genetic products and information on providers and their delivery of medical care. Challenges and solutions related to …
The Genomics Landscape
In the April 2024 issue of The Genomics Landscape, NHGRI Director Eric Green details how the Office of Genomic Data Science (OGDS) is becoming the epicenter for genomic data science at the institute, with numerous collaborations, projects and activities.
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… as well as provide animal models for future studies of drug intervention. Dr. Pavan’s group continues to identify … adeno-associated virus vector types (AAV9) and also varied delivery methods to NPC1 mouse mutants, then evaluating …
News Release
The U.S. National Institutes of Health (NIH) has long invested in basic genetics and genomics research, clinical trials, as well as translational medicine and social science studies, to advance our understanding of this widespread illness to help develop effective therapies.
… Today, the U.S. Food and Drug Administration (FDA) approved two gene therapies for the …
Office of Genomic Data Science
NHGRI is committed to increase the availability of educational and research opportunities in computational genomics and data science (CGDS).
… burdened by disparities in health status and health care delivery, including racial and ethnic minority groups, …
File
… providing leadership and resources to facilitate the delivery of high-quality clinical and laboratory medical … risk assessments and paternity and forensic computations. DELIVERY OF GENETIC AND GENOMIC HEALTH CARE The delivery of genetic and genomic health care often requires …
For Patients and Families
​Clinical research is research conducted with human subjects, or material of human origin, in which the researcher directly interacts with human subjects.
… phases: In Phase I clinical trials, researchers test a new drug or treatment for the first time in a small group of … side effects. In Phase II clinical trials, the study drug or treatment is given to a larger group of people (about … patients with the particular disease, to see if the drug or treatment is effective, and to further evaluate its …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… you could figure out patterns of toxicity of potential new drug compounds by looking at cellular responses and finding … responses to drugs was more accurate than conventional drug-potency tests. This recognition may point the way toward … and diseased human cells. Dr. Sorger hopes that future drug developers will be able to perform computations on LINCS …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… account a person's genetic information regarding specific drug receptors and how drugs are transported and metabolized … goal of pharmacogenetics is to create an individualized drug therapy that allows for the best choice and dose of drugs. One example is the breast cancer drug trastuzumab (Herceptin). This therapy works only for …