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- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Genomic Innovator Awards1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
- Ethical, Legal and Social Implications (ELSI) Research Program2
- Genomics-Enabled Learning Health Systems (gLHS)1
News Release
NIH researchers searched for how the body signals the lack of oxygen in melanoma skin cancer.
… in the original tumor site, the cancer cells travel to other parts of the body (metastasize) to find more … nutrients in many types of cancer. They discovered 40 new genes that are either turned on or off by HIF1α, and 10 genes … 2016, melanoma is one of the leading causes of skin cancer-related deaths, according to the National Cancer Institute at …
Research Funding
Effort to accelerate understanding of the molecular basis of cancer using genome analysis technologies, including large-scale genome sequencing.
… The Cancer Genome Atlas (TCGA) was a joint effort of the National … website . The Cancer Genome Atlas began with a pilot to assessed the feasibility of a full-scale effort to … Partnerships Anna D. Barker find that pinpointing the genes involved in cancer will help chart a new course across …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data.
… They use the gene expression and functional element data to construct gene regulatory network models, taking advantage … data to understand what elements are controlling what genes, in what cell types. The ability to make accurate … keratinocytes … Overview … Grantees … Program Staff … Related Content … The Genomics of Gene Regulation (GGR) …
News Release
NHGRI researchers identified 59 genes or gene regions linked to canine athletics.
… researchers reached this conclusion after identifying 59 genes or gene regions linked to canine athletics, including those with roles in endurance, … also homed in on the function of six of the 59 genes also related to athletic performance ( ADRB1, ASIC3, RYR3, TRPM3, …
News Release
NIH has awarded grants of more than $28 million aimed at deciphering the language of how and when genes are turned on and off.
… million aimed at deciphering the language of how and when genes are turned on and off. These awards emanate from the … is a growing realization that the ways genes are regulated to work together can be important for understanding disease," … visit http://www.nih.gov . … How and When Genes Turn On … Related Content … NIH grants aim to decipher the language of …
Talking Glossary
La interacción genes–ambiente se refiere a interrelación de los genes (y en términos más amplios, de la función del genoma) y el entorno físico y social.
… Interacción genes-ambiente … La interacción genes–ambiente se refiere a interrelación de los genes (y en … físico y social. … Gene–environment interaction refers to the interplay of genes (and, more broadly, genome …
News Release
NIH researchers demonstrated that gene therapy may be the best method for correcting the single faulty gene that causes Niemann-Pick disease, type C1.
… mice with the disease; the treated animals were then found to have less severe NPC1 symptoms. … The study, led by … The disease occurs when a faulty housekeeping gene fails to remove cell waste, like lipids and cholesterol. The … its programs, visit www.nih.gov . … A Promising Therapy … Related Content … Gene therapy shows promise for treating …
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… in ovarian cancer and in malignant mesothelioma as a means to home in on regions of the genome containing putative tumor suppressor genes. While at Massachusetts General Hospital/Harvard … mutant FBXW7 in the dysregulation of other cancer-related proteins in serous endometrial cancer cells, …
News Release
An expert panel from the Clinical Genome Resource (ClinGen) has critically reevaluated the scientific evidence for all 17 reported genes, disputing nine of the genes and revealing only three of the genes to be definitively associated with the most common form of the disease.
… Ph.D. … NIH-funded ClinGen panel also validates three genes believed to be associated with long QT syndrome … Geneticists and … panels working on different diseases — breast and ovarian cancer, glaucoma and familial hypercholesterolemia to name a …
Educational Resources
A complex disease is caused by the interaction of multiple genes and environmental factors.
… A complex disease is caused by the interaction of multiple genes and environmental factors. … Genes, Cancer, Heart Disease, Gene-environment Interactions … A … called multifactorial diseases. This stands in contrast to a “simple” genetic disease that is more directly caused by …