Search Results
Facet (Page)
Refine Your Search
Audiences
Content Formats
Sections
Divisions
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… this hypothesis, the researchers genetically engineered mice with FMF-causing genomic variants. They infected both healthy and genetically engineered mice with Yersinia pestis . Their results showed that infected mice with the FMF-causing genomic variant had significantly …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2021.
… or Bioengineering and Biomedical Imaging Research (R01) 27 Knockout Mouse Phenotyping Project (KOMP2) KOMP2 Program … Consortium RFA-HG-21-036 - Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) RFA-HG-21-037 - Limited Competition: Knockout Mouse Phenotyping Project Data Coordination Center …
Research Funding
Expired Funding Opportunity Announcements dating back to 1994, including Requests for Application, Program Announcements and Notices.
… Trial Not Allowed) RFA-HG-21-036 : Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) … Health (R01) PAR-13-231 : Phenotyping Embryonic Lethal Knockout Mice (R01) RFA-ES-16-003 : K22 BD2K Mentored Career …
Infographic
The X chromosome is part of sexual development and many other biological processes, including how some cats get their distinctive coat colors.
… The X chromosome plays a key function in aging. Mice with an XX genotype live longer than mice with XY, even if they have testes! The X chromosome …
News Release
A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.
… and the fish are far less costly to maintain than are mice. They multiply astonishingly quickly; a female may … Research paper. The CRISPR/Cas9 methodology works in mice, too, but it is more costly and takes far longer. Although mice actually reach sexual maturity earlier than zebrafish, …
Event
The 2018 meeting focused on KOMP's collaborations with various human disease gene discovery programs.
… Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International …
Staff
Dr. Lisa Helbling Chadwick is a program director in Division of Extramural Research at the National Human Genome Research Institute.
… HF. Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval . Genetics , … influences on X chromosome choice in Xce heterozygous mice . Mamm Genome, 16(9):691-9. 2005. … Biography … …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2022.
… Emphasis Overview Scientific Areas of Emphasis Search 31 Knockout Mouse Phenotyping Project (KOMP2) KOMP2 Program … Phenotyping Consortium Website Fell et al. – “NIH Renews Knockout Mouse Project for 3rd Time” 32 Human Heredity & …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… place in the petri dish and in nonhuman organisms such as mice or zebrafish. Researchers rely on genome editing tools … A typical study might be to model human disease in mice by deleting or editing certain genes that are thought to …
Research at NHGRI
The Genetic Disease Research Branch studies how genetic changes affect the structure and function of gene products leading to human disease.
… development. Model systems, including genetically altered mice and in vitro cell and organ culture systems, are major …