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Educational Resource
A step-by-step printable guide for folding a transfer RNA (tRNA) paper model.
… The tRNAs serve as links between the messenger RNA (mRNA) and the growing protein molecule. The mRNA is read out in sets of three letters called codons, and … block of proteins. By pairing with certain codons on the mRNA molecule, the tRNA ensures that the appropriate amino …
Fact Sheet
Sickle cell disease resources for healthcare providers
… welcomes your feedback about the sickle cell disease gene therapy resources. Please email your comments or questions to … are meant to promote your general understanding of gene therapy for sickle cell disease. We encourage you to use … Shared Decision Making ASGCT Lunch and Learn Webinar: Gene Therapy 101 … CDC Scientific Articles about SCD National …
Fact Sheets
Genomics is the study of all of a person's genes (the genome), including interactions of those genes with each other and with the person's environment.
… DNA into a molecule called messenger ribonucleic acid (mRNA). The mRNA travels out of the nucleus and into the cell's … though recent genome-driven efforts in lipid-lowering therapy have considerably shortened that interval. According …
Staff
Dr. David Bodine is the chief of and senior investigator in NHGRI's Genetics and Molecular Biology Branch.
… Hematology. The American Society of Gene and Cell Therapy has elected Dr. Bodine to serve as President, … Gallagher PG, Bodine DM. Long term expression of g-globin mRNA in mouse erythrocytes from retrovirus vectors containing … Jordan CT, Anderson SM, Cline AP, Bodine DM. The level of mRNA encoding amphotropic retrovirus receptor in mouse and …
Event
A joint NHGRI-NCATS hosted meeting bringing together researchers, clinicians, families and patient advocates from around the world to discuss the natural history, disease pathophysiology, genetics and treatments for rare inborn metabolic errors.
… A. Chapman, M.D., Ph.D. 3:10 - 3:30 p.m. Systemic AAV gene therapy for propionic acidemia (PA) Randy Chandler, Ph.D. … David S. Rosenblatt, M.D. 10:30 - 10:45 a.m. High-Dose B12 Therapy for cblC Deficiency Irini Manoli, M.D., Ph.D. 10:45 - … p.m. Treatment of CBS Deficient Mice by AAV-Mediated Gene Therapy Warren Kruger, Ph.D. 2:30 - 3:00 p.m. Break Session …
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… Chicago Chemical modifications on mammalian messenger RNA (mRNA) have recently been shown to play critical and diverse regulatory roles in mRNA metabolism and translation. For example, the most abundant mRNA modification, N6-methyladenosine (m6A), is crucial for …
News Release
NHGRI has selected Charles Venditti, M.D., Ph.D., as chief of its Metabolic Medicine Branch within the Institute’s Intramural Research Program. In this role, he will provide leadership and guidance on research into genetic diseases that disrupt metabolism.
News Release
NIH researchers have developed a breath test that measures how well patients with methylmalonic acidemia (MMA) respond to receiving liver or combined liver and kidney transplantation.
… increase in carbon 13 propionate oxidation after gene, mRNA or genome editing therapies,” Venditti said. “This way, …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… kinds of RNA. The major type, called messenger RNA (mRNA), plays a vital role in making proteins. In this process: mRNA is transcribed from genes; then the mRNA transcripts are delivered to ribosomes , the molecular …
For Teachers
Tools and resources for teaching the concepts of transcription and translation, two key steps in gene expression
… of a gene sequence. This copy, called a messenger RNA (mRNA) molecule, leaves the cell nucleus and enters the … process of translating the sequence of a messenger RNA (mRNA) molecule to a sequence of amino acids during protein … the cell cytoplasm, the ribosome reads the sequence of the mRNA in groups of three bases to assemble the protein. Here …