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Staff
Dr. Laura Koehly is the chief of and senior investigator in the Social and Behavioral Research Branch at the National Human Genome Research Institute.​
… Koehly is particularly interested in how genetic/genomic risk information can be used to activate network processes to … of healthcare services and dissemination of genetic risk information. Ultimately, her research aims to develop … effective strategies to help families cope with disease-risk information, to increase patients' willingness to share …
News Release
As researchers uncover millions of DNA differences in genes, doctors struggle to know which of these inherited differences, called variants, really matter.
… about genomic variants to evaluate individual disease risk, make better diagnoses, develop more appropriate disease … have strong evidence that mutations dramatically raise the risk for breast and ovarian cancer. Yet for many genes and … ​ … Genomic medicine, ClinGen, gene variants, disease risk, Heidi Rehm, genome sequencing, Jonathan Berg … As …
News Release
20 papers published online in 2014 highlight research on DNA biorepositories and electronic medical records to better understand the genomics of disease.
… The major goal of eMERGE is to better understand disease risk and susceptibility and, ultimately, improve patient … developing screening methods for individuals who are at risk for severe side effects from taking thiopurine drugs, … would like to be able to use this information to improve risk assessment and treatment for these and other disorders. …
15 Ways Genomics Influences Our World
Advances in genomics are helping you access information about your genome from your home.
Staff
Lindsey Criswell, who became the director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases in February, 2021 is also an associate investigator in NHGRI's Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
… Disease Genomics Branch. … Lindsey Criswell, genetic risk factors, autoimmune disease, rheumatoid arthritis (RA); …
Research Training
This program offers training in a combined program of maternal-fetal medicine and medical genetics.
… of genetic and metabolic disease on healthy and high risk pregnancies. The four year training program is open only … Genetic And Metabolic Disease, Healthy Pregnancies, High-risk Pregnancies, Obstetrics And Gynocology, Amniocentesis, …
Fact Sheet
Diversity among genomics research participants is essential for improving the health of everyone.
… all populations. … Every human has some baseline genetic risk of developing a given disease. Extensive research has … levels. This way, researchers can better define a person's risk of developing a specific disease and design a clinical … the Wellcome Trust and the African Academy of Sciences.   Polygenic Risk Score (PRS) Diversity Consortium (2021 - 2027) …
The Genomics Landscape
In the August 2023 edition of The Genomics Landscape, NHGRI Director Eric Green introduces incoming NHGRI DEO Director, Jennifer Troyer.
… will be notified by mid-October 2023. All the best,   … Polygenic scoring accuracy varies across the genetic ancestry … the case that variants in many genes contribute to the risk of developing traits and diseases. Scientists and clinicians use tools called polygenic scores to calculate such a risk by combining information …
Research Funding
The E​MERGE Network develops, disseminates and applies approaches to research that combine biorepositories with electronic medical record systems.​
… and Missions   Working Group Co-Chairs Goals Comprehensive Risk Assessment and Return Gail Jarvik, Iftikhar Kullo, and … and Management Network aims to: calculate and validate polygenic risk scores (PRS) in diverse populations for 10 conditions, …
News Release
NIH-led study finds genetic markers that explain up to 12% of the differences between two people’s blood pressure.
… differences in people’s blood pressure. Knowing a person's risk for developing hypertension could lead to tailored … these analyses, the researchers were able to calculate a polygenic risk score, which combines the effects of all … blood pressure and risk for hypertension. These risk scores consider which genomic variants confer risk for …