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- Ethical, Legal and Social Implications (ELSI) Research Program6
- Genomics-Enabled Learning Health Systems (gLHS)2
- Genetic Architecture of Complex Traits1
- Genome Technology Program5
- Human Genome Reference Program (HGRP)2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Encyclopedia of DNA Elements (ENCODE) Project1
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- Genomic Innovator Awards2
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)3
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
- Developmental Genotype-Tissue Expression (dGTEx)1
- Multi-Omics for Health and Disease (Multi-Omics)1
Staff
Dr. Heidi Parker is an Associate Investigator in the Comparative Genetics Section of the Cancer Genetics and Comparative Genomics Branch, NHGRI.
… Investigator in the Comparative Genetics Section of the Cancer Genetics and Comparative Genomics Branch at the National Human Genome Research Institute of NIH. She earned her Ph.D. from … hybridization on modern dog breed development . Cell Reports 19(4):697-708, 2017. Decker B*, Parker HG *, …
Educational Resources
BRCA1 and BRCA2 are the first two genes found to be associated with inherited forms of breast cancer.
… found to be associated with inherited forms of breast cancer. … Breast Cancer, Prostate Cancer, Genetic Mutation, Genes, DNA Repair, … act as tumor suppressors, meaning they help to regulate cell division. Most people have two active copies of these …
News Release
NHGRI researchers have released new educational materials to help the sickle cell disease community learn about gene therapies for the disease.
… emerging developments in gene therapies for sickle cell disease. … New educational materials to help the sickle cell disease community learn about gene therapies for the … are now available from researchers at the National Human Genome Research Institute (NHGRI), part of the National …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… Genome editing is currently being applied to research on … and somatic  therapy. Germline therapies can alter many cell types but by definition they also change genes in …
Educational Resources
Sickle cell disease is a hereditary disease seen most often among people of African ancestry.
… Sickle Cell Disease … Sickle cell disease is a hereditary disease seen most often among … Gene, Inherited, Mutation, Protein, Recessive … Sickle cell disease is a hereditary disease seen most often among …
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… Hydractinia  is dissimilar to humans physiologically, its genome contains a surprisingly large number of genes. Piwi1-positive spermatogonia are shown in yellow; cell nuclei are in turquoise. Germ cell induction and all stages of gametogenesis can be …
News Release
NIH researchers and collaborators have found that that sickle cell trait is prevalent among diverse human populations.
… Study finds that sickle cell trait is prevalent among diverse human populations. … … collaborators have found that being a carrier for sickle cell disease, known as having sickle cell trait , increases … Blood Advances , was led by researchers at National Human Genome Research Institute (NHGRI), part of NIH, The Johns …
News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.
… … As public interest and expanded research in human genome editing grows, many questions remain about ethical, … asked patients, parents and physicians in the sickle cell disease community what they wanted and needed to know … treatments, which appear to provide a potential for sickle cell, are among the most widely publicized medical advances …
The Genomics Landscape
In the June 2020 edition of The Genomics Landscape, NHGRI Director Eric Green details NHGRI's new Diversity in Genomics Workforce Initiative.
… up to the 30th anniversary of the launch of the Human Genome Project in October 2020. I encourage you to check out … gene-editing therapy to cure an individual with sickle cell disease. This has been heralded as a landmark moment for … and health disparities lecture – Subtype-specific breast cancer risk in highly indigenous Latin American women, Laura …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted … gene therapy for humans. Researchers at the National Human Genome Research Institute (NHGRI), part of NIH, published … to deliver the corrected gene to a specific point in the cell's DNA. AAVs are small viruses that infect humans but do …