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Research at NHGRI
The Genetic Disease Research Branch studies how genetic changes affect the structure and function of gene products leading to human disease.
… development. Model systems, including genetically altered mice and in vitro cell and organ culture systems, are major …
News Release
Researchers from the NHGRI-funded Impact of Genomic Variation on Function Consortium are exploring how genomic variation affects genome function.
… in regulating other genes and in various organs in mice. They also plan to understand these variants in female versus male mice and in mice with and without inflammation. The specific variants …
Staff
Dr. Pamela Schwartzberg is a adjunct investigator in NHGRI's Genetic Disease Research Branch.
… recombination to introduce mutations into the germline of mice — work that helped open a new era in mouse genetics. … genetic primary immunodeficiencies, as well as mutant mice and cell lines, have demonstrated that pathways … Specific projects: Tec Kinases: Through the generation of mice deficient in Rlk and Itk, Dr. Schwartzberg's lab has …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… that affect humans. They edit the genomes of animals, like mice and zebrafish, because animals have many of the same genes  as humans. For example, mice and humans share about 85 percent of their genes! By …
Staff
Darryl Leja is a senior graphic designer, illustrator and visual information specialist within NHGRI's Office of Communications.
… entitled "Training in Basic Biomethodology for Laboratory Mice," DNA Day, the Genome Unlocking Life’s Code Exhibit on …
About Genomics
In 2003, an accurate and complete human genome sequence was finished two years ahead of schedule and at a cost less than the original estimated budget.
Staff
Dr. Paul Liu is a senior investigator in NHGRI's Translational and Functional Genomics Branch.
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… et al., Cell 1996). Using the Cbfb-MYH11 knock-in mice (in which human MYH11 was inserted into mouse Cbfb to … by microarray analysis with cells from Cbfb-MYH11 knock-in mice, and identified leukemia-initiating cells using these … Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukemia. Nat Genet, 23:144-146. …
File
… Knockout Mouse Phenotyping Program Concept Clearance (May …
Fact Sheets
Cloning describes a number of different processes that can be used to produce genetically identical copies of a biological entity.
… 1979, researchers produced the first genetically identical mice by splitting mouse embryos in the test tube and then … the resulting embryos into the wombs of adult female mice. Shortly after that, researchers produced the first … cell division. In other mammals, such as cats, rabbits and mice, the two spindle proteins are spread throughout the egg. …
News Release
The largest genomic study on type 2 diabetes in Africans to date has recently been published in Nature Communications and reports the most recent findings of the ongoing Africa America Diabetes Mellitus (AADM) study that has been led by Dr. Charles Rotimi for over two decades.
… functional studies of this locus in zebrafish and mice, researchers discovered that ZRANB3 plays a role in the …