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News Release
New grants totaling approximately $29.5 million will enable scientists to generate and maintain the most comprehensive reference sequence of the human genome.
… The funds are necessary for making advances in DNA sequencing technology and computational methods possible. As … will represent 350 genomes from the human population. The sequencing of the human genome was a landmark achievement in … The second component – the Human Reference Genome Sequencing Center - aims to sequence up to 350 additional …
Educational Resources
A stop codon is a trinucleotide sequence within a messenger RNA (mRNA) molecule that signals a halt to protein synthesis.
… synthesis. … Amino Acids, Cell, Codon, Deoxyribonucleic Acid (DNA), Gene Environment Interaction, Genetic Code, …
Staff
Dr. Mullikin was the former director of the NIH Intramural Sequencing Center (NISC).
… to analyze large data sets generated by systematic DNA sequencing projects. A highly skilled computational … analysis package called "Image", custom-modified 60 ABI377 sequencing machines to scan 96 lanes, developed a blazingly … changes resulting in synonymous or non-sysnonymous amino-acid changes, splice-site, etc); and has predicted effects of …
Educational Resources
A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest.
… of interest. … Chromosome, Gene, Deoxyribonucleic Acid (DNA), Positional Cloning … A physical map, as related …
Educational Resources
Polymerase chain reaction (PCR) is a laboratory technique used to amplify DNA sequences.
… used to amplify DNA sequences. … Deoxyribonucleic Acid (DNA), DNA Replication, Enzyme, Genome, Primer … …
Educational Resources
A promoter is a sequence of DNA needed to turn a gene on or off.
… of DNA needed to turn a gene on or off. … Deoxyribonucleic Acid (DNA), Enzyme, Gene, Gene Expression, Gene Regulation, …
Media Advisory
The National Institutes of Health (NIH) will host researchers from the Telomere-to-Telomere (T2T) consortium, who have now sequenced the remaining 8% of DNA that was unable to be sequenced by the Human Genome Project and has eluded researchers for nearly two decades.
… What: Virtual press conference to announce T2T consortium sequencing a complete human genome Moderator: Eric Green, …
News Release
A team of NIH-funded researchers have generated the first complete chromosome sequences from non-human primates.
… has only become possible in recent years due to new DNA sequencing technologies and analysis methods. These …
Educational Resources
A restriction enzyme is an enzyme isolated from bacteria that cuts DNA molecules at specific sequences.
… at specific sequences. … Bacteria, Deoxyribonucleic Acid (DNA), Enzyme, Genetic Engineering, Recombinant DNA …
Staff
Dr. James Thomas is the acting director for the NIH Intramural Sequencing Center (NISC).
… Dr. James Thomas is the director of the NIH Intramural Sequencing Center. He oversees the importation and use of DNA sequencing technologies, protocols and analyses, ensuring … genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing …