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- Genomics-Enabled Learning Health Systems (gLHS)2
- Ethical, Legal and Social Implications (ELSI) Research Program6
- Genetic Architecture of Complex Traits1
- Genome Technology Program5
- Human Genome Reference Program (HGRP)2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Encyclopedia of DNA Elements (ENCODE) Project1
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- Genomic Innovator Awards2
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)3
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
- Developmental Genotype-Tissue Expression (dGTEx)1
- Multi-Omics for Health and Disease (Multi-Omics)1
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… agents and their effects on the development of a cell’s normal state. In addition, LINCS developed a resource … broader biomedical enterprise. …  NHGRI and the National Cancer Institute (NCI) are partnering to fund grants totaling … the status of the evolutionary synthesis after the Human Genome Project; and recent work in human genomic variation. … …
Fact Sheet
Learn about the different types of hemoglobin.
… To understand sickle cell disease and gene therapy , you should first know about … make up red blood cells. … Hemoglobin types and sickle cell disease  Your red blood cells contain hemoglobin , a … oxygen to your body’s organs and tissues. Every red blood cell contains thousands of hemoglobin molecules.   The …
News Release
Researchers used whole genome sequence data to investigate the origin of the mutation that causes "sickling" of red blood cells.
… on Genomics and Global Health (CRGGH), have used whole genome sequence data to investigate the origin of the … of the sickle allele will help clinicians redefine sickle cell subgroups and treat patients more effectively. This … "sickling" of red blood cells. ​ … Sickle allele, Sickle cell disease, Center for Research on Genomics and Global …
News Release
NIH investigators have discovered that genomic switches of a blood cell are key to regulating the human immune system.
… (NIH) have discovered the genomic switches of a blood cell are key to regulating the human immune system. The … and Metabolic Genetics Branch at the National Human Genome Research Institute (NHGRI). Autoimmune diseases occur … M.D., Nicholas P. Restifo, M.D., at the NIH's National Cancer Institute, and Yijun Ruan, Ph.D., at The Jackson …
Clinical Research
The INSIGHTS study is exploring sickle cell disease in adults.
… into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS) study is exploring sickle cell disease in adults by looking at many factors, including … in helping researchers understand how your environment and genome may impact your sickle cell disease? Are you …
News Release
NIH grants aim to gauge if genomics can be used to help diagnose diabetes, manage heart disease and guide cancer clinicians to the most effective drugs.
… keep heart disease patients out of hospitals and guide cancer clinicians and patients to the most effective drugs. … … (IGNITE) program administered by the National Human Genome Research Institute (NHGRI), part of NIH. All three … on genomically guided prescriptions of cardiovascular and cancer drugs. David Flockhart, M.D. , Ph.D. , Indiana …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… is a collection of all the gene readouts present in a cell. … The human genome is made up of DNA (deoxyribonucleic acid), a long, … gene's expression levels are dramatically higher in cancer cells than in healthy cells, the unknown gene may play …
Educational Resources
The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes.
… Nucleolus … The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes. … Messenger RNA (mRNA), Ribonucleic Acid (RNA), Translation, Cell, Cytoplasm, Protein, Nucleus, Ribosome … The nucleolus …
News Release
Researchers identified regions of the genome associated with skin color variation in some African populations, furthering skin disease and cancer research.
… researchers has identified new regions of the human genome that are associated with skin color variation in some … opening new avenues for research on skin diseases and cancer in all populations. … These findings may help … new pathways for studying pigmentation and pigment cell diseases," said William Pavan , Ph.D., co-author of the …
Educational Resources
A nucleus is a membrane-bound organelle that contains the cell's chromosomes.
… A nucleus is a membrane-bound organelle that contains the cell's chromosomes. … Chromosome, Cell, Deoxyribonucleic Acid (DNA) … A nucleus, as related to genomics, is the membrane-enclosed organelle within a cell that contains the chromosomes. An array of holes, or …