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Transcription is the process of making an RNA copy of a gene sequence.
… … Cell, Cytoplasm, Deoxyribonucleic Acid (DNA), Gene, Gene Expression, Messenger RNA (mRNA), Nuclear Membrane, Nucleus, …
The Genomics Landscape
In the August 6, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about NHGRI's completion of the third phase of the ENCODE Project and how it reveals the most extensive catalog to date of candidate functional elements that may regulate the genes in the human and mouse genomes.
… to DNA, and how RNA molecules interact to regulate gene expression. The results reported in the ENCODE 3 publications … outside of protein-coding regions can influence gene expression. The ENCODE Project began in 2003, shortly after … a new initiative, the Developmental Genotype-Tissue Expression ( dGTEx ) Project. The goal of dGTEx is to …
About Genomics
In 2003, an accurate and complete human genome sequence was finished two years ahead of schedule and at a cost less than the original estimated budget.
… Human Genome Sequencing, Long-range Planning, Gene Expression, Sequence Variations, Phenotypes, Large-scale …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… genetic contributions from either parent, they found that expression in 95 genes in the brain depended more on being … of genes in the brain, there was a slightly greater expression of genes inherited from the father than from the … ARTICLE: Crowley, et al . Analyses of allele-specific gene expression in highly divergent mouse crosses identifies …
Staff
Dr. Neil Hanchard is a clinical investigator within the Center for Precision Health Research (CPHR) and head of the Childhood Complex Disease Genomics Section within the CPHR.
… genome-wide significant association between an intergenic locus on chromosome 5q33 and being a transfusion responder … and transcriptomic technologies alongside population and quantitative genetics to identify the genes and gene-pathways … ER, Hanchard NA, Wonkam A. Hydroxyurea-Induced miRNA Expression in Sickle Cell Disease Patients in Africa. Front …
Staff
Dr. Wilson is the co-chief of and senior investigator in NHGRI's Computational and Statistical Genomics Branch.
… that may be responsible for phenotypic variation in quantitative traits (e.g., traits related to cardiovascular … and non-coding elements that may be responsible for their expression, and the investigation of the statistical … RM. Use of the robust sib-pair method to screen for single-locus, multiple-locus, and pleiotropic effects: application …
Staff
Dr. Charles Rotimi is the scientific director of and NIH Distinguished Investigator in the Division of Intramural Research. He also serves as the director of the Center for Research on Genomics and Global Health (CRGGH).
… with more than 2 million markers, and (3) whole genome expression analysis on skeletal muscle obtained from biopsy … Comuzzie AG, Lowe WL, Luke A, Blangero J, Cooper RS. The quantitative trait locus on chromosome 2 for serum leptin levels is …
Research at NHGRI
NHGRI researchers develop freely available software and analysis tools to help researchers around the world analyze and explore their genomic data.
… genetic association studies. ROMPrev A software suite for quantitative trait and locus-specific heritability estimation and association …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… modeling studies demonstrated that neuronal-targeted expression of NPC1 rescued neurodegenerative disease, … Dr. Pavan’s group has collaborated to identify expression quantitative trait loci (eQTL) in a large cohort of primary melanocytes, …
Research at NHGRI
CRGGH uses genomic tools to understand the pathobiology of metabolic disorders, including obesity, hypertension, diabetes, dyslipidemia, and kidney disease.
… and excretion (ADME) of pharmaceutical drugs. Gene expression RT-PCR for genes of interest using Applied … chemistry on BIO-RAD instruments (MyiQ). Whole genome gene expression array, such as the GeneChip® Human genome U133 … regression model to evaluate the association between the trait and variants in that region. The program executable and …