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The Genomics Landscape
In the October 2019 edition of The Genomics Landscape, NHGRI Director Eric Green focuses on recent efforts to make the human genome reference sequence useful to basic and clinical researchers and how increasing the representation of human genomic variation will remain key components of NHGRI’s Human Genome Reference Program.
… were difficult to “read out” completely using the DNA-sequencing methods available at that time. In addition, the … to be aligned and organized. Such a reference must be high quality and, preferably, enhanced over time as new … its continuing commitment to ensure the availability of a high-quality and maximally useful human genome reference …
Educational Resources
Epigenetics is an emerging field of science that studies heritable changes caused by the activation and deactivation of genes without any change in the underlying DNA sequence of the organism.
Educational Resources
A bacterial artificial chromosome (BAC) is an engineered DNA molecule used to clone DNA sequences in bacterial cells (for example, E. coli).
… E. coli). … Cloning, Bacteria, Bioengineering, DNA Sequencing, Base Pair, Chromosomes … A bacterial artificial … E. coli). BACs are often used in connection with DNA sequencing. Segments of an organism's DNA, ranging from … the BAC DNA, which can then be isolated and used in sequencing DNA. … A bacterial artificial chromosome (BAC) is …
Outreach
The Genome: Unlocking Life's Code exhibition celebrates the 10th anniversary of the initial sequencing of the human genome.
… the Smithsonian Institution in Washington, D.C. opened the high-tech, high-intensity exhibition Genome: Unlocking Life's Code to … exhibition celebrates the 10th anniversary of the initial sequencing of the human genome. … Human Genome Sequencing, …
News Release
NIH researchers have sequenced the whole genome of a dog native to Sardinia, Italy, and discovered in it clues about the migration of humans to the area.
… and guard humans as they have for hundreds of years. By sequencing the whole genome of a Fonni's Dog and comparing it … the migration of humans to the area. … Sardinian dog sequencing, human migration, Fonni's Dogs, Sardinian's …
About Genomics
Resources for understanding the first truly complete sequence of the Y chromosome, the final human chromosome to be fully sequenced.
News Release
The goat has contributed its DNA to a new method for high-quality, low-cost genome reconstruction, one that will be useful for reading human and other genomes.
… its DNA to a study that presents a new method for high-quality, low-cost genome reconstruction. In addition to … contributed DNA to a study that presents a new method for high-quality, low-cost genome reconstruction. Credit: Brian L … researchers used a variety of methods, including PacBio sequencing , which was released in 2011. Dr. Phillippy and …
News Release
Evaluating genetic features of inherited diseases by sequencing the genetic code helps with the cost and time challenges in medical practice.
… all potential genetic features of inherited diseases by sequencing the genetic code is a powerful solution to … get in there and start touching patient data." Through new sequencing technologies, data is accumulating in an … M.D., Ph.D. But how do we make sure that using genome sequencing for disease diagnosis, treatment and prevention …
News Release
North Asians may be more closely related to Eastern and Northern Europeans than previously thought.
… from precision medicine." The researchers constructed a high quality genetic variation panel that represents people … This includes a number of coordinated large scale sequencing projects such as the HapMap and 1000 Genomes … previously thought. … genetic diversity, ancestry, genome sequencing, Lawrence Brody … North Asians may be more closely …
Educational Resources
A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to ionizing radiation, exposure to chemicals called mutagens, or infection by viruses.