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- Genome Technology Program3
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
- Developmental Genotype-Tissue Expression (dGTEx)1
- Ethical, Legal and Social Implications (ELSI) Research Program1
- Genomics-Enabled Learning Health Systems (gLHS)1
News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.
… asked patients, parents and physicians in the sickle cell disease community what they wanted and needed to know … treatments, which appear to provide a potential for sickle cell, are among the most widely publicized medical advances … of the Bioethics Core at NHGRI. “By talking to sickle cell disease stakeholders ahead of time, we can learn more …
Talking Glossary
A gamete is a reproductive cell of an animal or plant.
… Gamete … A gamete is a reproductive cell of an animal or plant. … A gamete is a reproductive cell of an animal or plant. In animals, female gametes are … called sperm. Ova and sperm are haploid cells, with each cell carrying only one copy of each chromosome. During …
News Release
NHGRI is awarding Genomic Innovator Awards to nine institutions to support the research of 12 early career scientists in the field of genomics. The awards will total up to $27 million over five years.
… of Medicine, Stanford, California Improve understanding of single-cell biology by applying molecular engineering and … CRISPR, non-coding DNA and RNA sequences, gene regulation, single-cell biology, chromatin state features, chromatin …
Talking Glossary
Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of proteins that the gene encodes.
News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… spleen, bone marrow and nervous system. The main type of cell that is affected by accumulated glucocerebroside is the macrophage, a type of white blood cell. Macrophages are cellular housekeepers that dispose of cell debris and pathogens. According to the study, …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… agents and their effects on the development of a cell’s normal state. In addition, LINCS developed a resource … “signatures” that reflect the responses that different cell types show under different conditions. LINCS was based … cellular characteristics, behavior, and/or function of a cell. In the past, most research studies designed to …
Fact Sheets
Chromosomes are thread-like structures located inside the nucleus of animal and plant cells.
… and plant cells. Each chromosome is made of protein and a single molecule of deoxyribonucleic acid (DNA). Passed from … Scientists gave this name to chromosomes because they are cell structures, or bodies, that are strongly stained by some … cells. For example, if all of the DNA molecules in a single human cell were unwound from their histones and placed …
News Release
NHGRI has selected James Thomas, Ph.D., as the new director of the NIH Intramural Sequencing Center (NISC), to will oversee the importation and use of DNA sequencing technologies, protocols and analyses, ensuring that NIH investigators have access to cutting-edge DNA sequencing methods and specialized genomics protocols to meet their research needs.
… and use of DNA sequencing technologies, protocols and analyses, ensuring that NIH investigators have access to … response. NISC also provided DNA sequencing and data analyses to the Telomere-to-Telomere Consortium and the Human … and use of DNA sequencing technologies, protocols and analyses, ensuring that NIH investigators have access to …
Fact Sheet
Ribonucleic acid (RNA) is an essential molecule that performs many roles in the cell, from carrying the instructions to make proteins to regulating genes.
… a ladder-like structure, RNA is often, but not always, single-stranded. These structural differences help these … DNA, and this information helps the RNA do its job in the cell. This process, where a gene produces RNA molecules, … use RNA as their genetic material. Sometimes this is a single strand of RNA, and sometimes the RNA forms a …
Educational Resources
The genome is the entire set of genetic instructions found in a cell.
… is the entire set of genetic instructions found in a cell. … Genome, Genomics, DNA Sequence, Human Genome Project, … genome is the entire set of DNA instructions found in a cell. In humans, the genome consists of 23 pairs of chromosomes located in the cell’s nucleus, as well as a small chromosome in the cell’s …