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Dr. Paul Liu is a senior investigator in NHGRI's Translational and Functional Genomics Branch.
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… that form a dimer for DNA binding and gene expression regulation, are frequent targets of such chromosome … Sood, has used zebrafish to study the roles of several transcription factor genes in hematopoiesis, such as runx1 , … Freedman M, Siciliano MJ, and Collins FS. Fusion between transcription factor CBFb/PEBP2b and a myosin heavy chain in …
Infographic
The X chromosome is part of sexual development and many other biological processes, including how some cats get their distinctive coat colors.
… one of the X chromosomes is inactivated . This stops transcription (creation of RNAs) from occurring, ensuring … chromosomes are rare and will have an XXY genotype. …  … Transcription … Related Video … Downloads … X Chromosome …
Research Training
Two-year fellowships for M.D.s and Ph.D.s in cytogenetics, biochemical genetics and molecular genetics.
Staff
Dr. Marjan Huizing is a staff scientist in the Medical Genetics Branch at the National Human Genome Research Institute.
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Research at NHGRI
NHGRI researchers develop freely available software and analysis tools to help researchers around the world analyze and explore their genomic data.
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… ZFN must be engineered for each new target DNA sequence. Transcription activator-like effector nucleases (TALENs) In 2009, a new class of proteins called Transcription Activator-Like Effector Nucleases (TALENs) …  arrived to the genome editing scene. Similar to ZFNs, transcription activator-like effector nucleases (TALENs) are …
Event
The Advances in Genomic Technology Development (AGTD) 2022 Annual Meeting was hosted by the Technology Development Coordinating Center (TDCC) from July 12-14, 2022 at The Jackson Laboratory (Farmington, CT).
… Technology for Highly Parallel Analysis of Variation in Transcription Factors and their DNA Binding Sites Shubham … Break 11:05 a.m. Keynote Single-cell Epigenomics: Gene Regulation at Unprecedented Resolution Panel Discussion with …
Research at NHGRI
The Genetic Disease Research Branch studies how genetic changes affect the structure and function of gene products leading to human disease.
… in understanding how disruptions in signaling pathways and transcription factors contribute to disease. Our …
Educational Resources
Messenger RNA (abbreviated mRNA) is a type of single-stranded RNA involved in protein synthesis.
… mRNA is made from a DNA template during the process of transcription. The role of mRNA is to carry protein …
The Genomics Landscape
In the February 2018 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the new director of NHGRI's Division of Genome Sciences.
… the Genome Technology Program; the Genomics of Gene Regulation (GGR); and several NIH Common Fund Programs - the …