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Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… used to control gene activity have many similarities in mice and humans. … What are the benefits of comparative …
Archive
… 1981-82: First Transgenic Mice and Fruit Flies … Archive …
News Release
NHGRI researchers, collaborators at the University of California (UC) San Diego, UC Davis and the University of Pittsburgh School of Medicine lay out a new framework for comparing dog-to-human aging, one that uses epigenetics as a biological marker to better understand the aging process.
… They do not seem to be valid across species, such as in mice, dogs, and wolves. To see why the epigenetic clocks in …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… studies of cultured cells, bacteria, fruit flies, mice and other organisms. Many of the pathways identified in …
Event
A joint NHGRI-NCATS hosted meeting bringing together researchers, clinicians, families and patient advocates from around the world to discuss the natural history, disease pathophysiology, genetics and treatments for rare inborn metabolic errors.
… Ph.D. 2:00 - 2:30 p.m. Treatment of CBS Deficient Mice by AAV-Mediated Gene Therapy Warren Kruger, Ph.D. 2:30 - …
News Release
Researchers show critical association between diabetes and previously unlinked ZRANB3 gene.
… such β-cell death, the researchers took β-cell cells from mice and performed a similar knockdown of the ZRANB3 gene as …
Genetic Disorders
Huntington's disease is an inherited neurological illness causing involuntary movements, severe emotional disturbance and cognitive decline.
… of the disease by breeding laboratory animals, such as mice, and attempting to duplicate the clinical features of …
The Genomics Landscape
In the November 2019 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the International Common Disease Alliance's scientific plenary and launch meeting in September, which included an international panel on opportunities emerging outside the U.S., North America, and Europe; discussions about polygenic risk scores; and an overview about data platforms, data sharing, and ethics.
… Schizophrenia risk gene linked to cognitive deficits in mice Scientists unveil search-and-replace genome editing …
Outreach
A list of high quality educational activities to engage students on DNA Day.
… or explore rapid evolutionary change through "rock pocket mice." Resources also discuss artificial vs. natural … relate to society. These topics include: "Transgenetic Mice", "Genetically Modified Foods", "Pharming for …
News Release
Doctors and researchers reunite with patient who received gene therapy for GM1 gangliosidosis.
… gene therapy to successfully treat GM1 gangliosidosis in mice and cats, it gave Dr. Tifft and her team enough hope to …