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- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
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Fact Sheet
mRNA vaccines inject cells with instructions to generate a protein that is normally found on the surface of SARS-CoV-2, the virus that causes COVID-19.
… Key Points mRNA vaccines inject cells with instructions to generate a protein that is … meaning it degrades easily and does not last long inside cells. By injecting cells with a synthetic mRNA that encodes a viral spike …
Genetic Disorders
Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply to form a tumor.
… and tissue around the prostate to check if the cancer cells have spread (called metastasis). Sometimes the surgery … is aimed directly at the tumor to kill the cancer cells. It is also used in later stages of prostate cancer to … Cancer … Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply without …
Event
Pre-application webinar on for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) program funding opportunity announcements (FOAs) on September 10, 2021.
… RFA-HG-21-029 - Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Production Research and … RFA-HG-21-030 - Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Analysis and Validation Centers … RFA-HG-21-031 - Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Resource and Administrative …
News Release
NIH researchers researchers and collaborators have gained some key insights into the biological inner-workings of regrowing a body, the evolution of aging and a unique method to dispose of aging cells, by studying the genomes of a hermit crab (Hydractinia symbiolongicarpus).
… and corals regrows its entire body with help from “aging” cells. … Insights into healing and aging were discovered by … researchers found that Hydractinia has a special group of stem cells for regeneration. Stem cells can transform into other types of cells, and are …
News Release
National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study may inform the development of treatments for hearing loss in humans.
… Ph.D., NHGRI. … Confocal image of adult zebrafish hair cells (green) in the auditory organ of the inner ear. Credit: … come from the loss of hearing receptors known as “hair cells” in the inner ear. Bristles that stick out of these … cells start replicating. These support cells are like stem cells because of their ability to become other cell …
Educational Resources
A lymphocyte is a type of white blood cell that is part of the immune system.
… immune system. There are two main types of lymphocytes: B cells and T cells. The B cells produce antibodies that are used to attack invading …
Staff
Dr. Sharon Milgram is an adjunct investigator in the Genetics and Molecular Biology Branch at the National Human Genome Research Institute.
… cell signaling and protein trafficking in polarized cells, including kidney and airway epithelial cells. Epithelial cells form a lining at the surface of the skin and along …
Educational Resources
Prostate cancer is a disease characterized by uncontrolled cell growth in the prostate gland, which is part of the male reproductive system.
Educational Resources
A bacterial artificial chromosome (BAC) is an engineered DNA molecule used to clone DNA sequences in bacterial cells (for example, E. coli).
… DNA molecule used to clone DNA sequences in bacterial cells (for example, E. coli). … Cloning, Bacteria, … DNA molecule used to clone DNA sequences in bacterial cells (for example, E. coli). BACs are often used in … with their inserted DNA, are then taken up by bacterial cells. As the bacterial cells grow and divide, they amplify …
Staff
Dr. Settara Chandrasekharappa is an associate investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… in vitro hematopoietic differentiation of mouse embryonic stem cells and this role of menin is mediated by its ability to … In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is …