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- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
- Developmental Genotype-Tissue Expression (dGTEx)1
Fact Sheets
Fluorescence in situ hybridization (FISH) provides researchers with a way to visualize and map the genetic material in an individual's cell.
… visualize and map the genetic material in an individual's cells, including specific genes or portions of genes. This …
Fact Sheets
Chromosome abnormalities can either be numerical or structural and usually occur when there is an error in cell division.
… "q" arm. … The body is made up of individual units called cells. Your body has many different kinds of cells, such as skin cells, liver cells and blood cells. In the center of most …
News Release
Cell Press' "Best of AJHG 2017-2018" includes an article authored by CRGGH researchers Daniel Shriner and Charles Rotimi.
… and how the mutation that causes "sickling" of red blood cells arose ( previous blog post ). This work captured …
Fact Sheet
mRNA vaccines inject cells with instructions to generate a protein that is normally found on the surface of SARS-CoV-2, the virus that causes COVID-19.
… Key Points mRNA vaccines inject cells with instructions to generate a protein that is … meaning it degrades easily and does not last long inside cells. By injecting cells with a synthetic mRNA that encodes a viral spike …
News Release
National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study may inform the development of treatments for hearing loss in humans.
… Credit: Erin Jimenez, Ph.D., NHGRI. … Confocal image of adult zebrafish hair cells (green) in the auditory organ of the inner ear. Credit: … cells start replicating. These support cells are like stem cells because of their ability to become other cell …
Genetic Disorders
Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply to form a tumor.
… and tissue around the prostate to check if the cancer cells have spread (called metastasis). Sometimes the surgery … is aimed directly at the tumor to kill the cancer cells. It is also used in later stages of prostate cancer to … Cancer … Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply without …
Event
Pre-application webinar on for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) program funding opportunity announcements (FOAs) on September 10, 2021.
… RFA-HG-21-029 - Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Production Research and … RFA-HG-21-030 - Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Analysis and Validation Centers … RFA-HG-21-031 - Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Resource and Administrative …
News Release
NIH researchers researchers and collaborators have gained some key insights into the biological inner-workings of regrowing a body, the evolution of aging and a unique method to dispose of aging cells, by studying the genomes of a hermit crab (Hydractinia symbiolongicarpus).
… and corals regrows its entire body with help from “aging” cells. … Insights into healing and aging were discovered by … researchers found that Hydractinia has a special group of stem cells for regeneration. Stem cells can transform into … Unlike human cells, which are locked in their fates, the adult cells of some highly regenerative organisms can revert …
Educational Resources
A lymphocyte is a type of white blood cell that is part of the immune system.
… immune system. There are two main types of lymphocytes: B cells and T cells. The B cells produce antibodies that are used to attack invading …
Staff
Dr. Sharon Milgram is an adjunct investigator in the Genetics and Molecular Biology Branch at the National Human Genome Research Institute.
… cell signaling and protein trafficking in polarized cells, including kidney and airway epithelial cells. Epithelial cells form a lining at the surface of the skin and along …