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- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
- Developmental Genotype-Tissue Expression (dGTEx)1
Fact Sheet
mRNA vaccines inject cells with instructions to generate a protein that is normally found on the surface of SARS-CoV-2, the virus that causes COVID-19.
… acts as a cellular messenger. DNA, which is stored in a cell’s nucleus, encodes the genetic information for making … of this genetic information outside of the nucleus, to a cell’s cytoplasm, where it is translated into amino acids by …
Genetic Disorders
Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply to form a tumor.
Event
Pre-application webinar on for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) program funding opportunity announcements (FOAs) on September 10, 2021.
News Release
National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study may inform the development of treatments for hearing loss in humans.
… shows the role of transcription factors in facilitating cell regeneration …  Brightfield image of a two-day-old … the potential for researchers to understand the biology of cell regeneration in zebrafish before translating the … learning, Jimenez and her collaborators found that hair cell regeneration in zebrafish relied on a network of …
Staff
Dr. Edward Giniger is an adjunct investigator in NHGRI's Genetics and Molecular Biology Branch.
… of fruit flies, a model system that allows biochemical and cell biological approaches to be merged with classical and … on the surface of fly nerve cells, called Notch, engages signaling proteins inside the axon that make it grow or turn … in Drosophila photoreceptor neurons. Mol Biol of the Cell, 25:2993-3005. 2014. [ PubMed ] Smith-Trunova, S., …
Educational Resources
A lymphocyte is a type of white blood cell that is part of the immune system.
… Lymphocyte … A lymphocyte is a type of white blood cell that is part of the immune system. … Lymphocytes, White Blood Cell, Immune System … A lymphocyte is a type of white blood cell that is part of the immune system. There are two main …
Educational Resources
Prostate cancer is a disease characterized by uncontrolled cell growth in the prostate gland, which is part of the male reproductive system.
… Prostate cancer is a disease characterized by uncontrolled cell growth in the prostate gland, which is part of the male reproductive system. … Cancer, Cell, Mitosis, Mutation … Prostate cancer is a disease characterized by uncontrolled cell growth in the prostate gland, which is part of the male …
Educational Resources
A bacterial artificial chromosome (BAC) is an engineered DNA molecule used to clone DNA sequences in bacterial cells (for example, E. coli).
Talking Glossary
Aneuploidy is an abnormality in the number of chromosomes in a cell due to loss or duplication. In humans, aneuploidy would be any number of chromosomes other than the usual 46.
… is an abnormality in the number of chromosomes in a cell due to loss or duplication. In humans, aneuploidy would … is an abnormality in the number of chromosomes in a cell due to loss or duplication. In humans, aneuploidy would … is an abnormality in the number of chromosomes in a cell due to loss or duplication. In humans, aneuploidy would …
News Release
NIH is launching a program, Molecular Phenotypes of Null Alleles in Cells (MorPhiC), to better understand the function of every human gene and generate a catalog of the molecular and cellular consequences of inactivating each gene.
… function and behave differently depending on the type of cell in which they are expressed. In addition, genes may turn on or off depending on the cell’s relationship to surrounding cells, environment and age. Research funded by the MorPhiC program will use cell culture models such as organoids, which are miniature, …