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- Ethical, Legal and Social Implications (ELSI) Research Program5
- Genomics-Enabled Learning Health Systems (gLHS)1
- Genome Technology Program4
- Human Genome Reference Program (HGRP)1
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- Genomic Innovator Awards1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
- Developmental Genotype-Tissue Expression (dGTEx)1
Staff
Dr. Shawn Burgess is the co-deputy director of NHGRI's Intramural Research Program.
… the last decade has been focused on developing efficient gene knockout technologies in zebrafish, coupled with efficient phenotyping of the gene disruptions. … For the last decade, the Burgess lab has … of the protein-coding genes could be assigned a putative function based on at least one identified Pfam domain. …
Fact Sheets
Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.
… epigenomic compounds attach to DNA and modify its function, they are said to have "marked" the genome. These … DNA and DNA-associated proteins in the cell, which alter gene expression, and are heritable (via meiosis and mitosis). … … The human genome contains two copies of every gene-one copy inherited from the mother and one from the …
Staff
Dr. Elise Feingold is a scientific program manager in NHGRI's Division of Genome Sciences.
… (then NCHGR) in 1992 as a program director focused on gene discovery, gene expression and functional genomics. Since 2019, Dr. … with the National Cancer Institute, the Mammalian Gene Collection project, which created a comprehensive …
News Release
NIH will renew three awards totaling $73.2 million over five years to continue building the Clinical Genome (ClinGen) resource, an effort to collect and archive information about clinically relevant genes and genomic variants for use in precision medicine.
Clinical Research
The CLINSEQ® Study seeks to learn about the role that your genes play in your health.
… Free CAT scan to detect coronary artery disease.  Finding gene changes that are important to your health and/or the … LG. Determining the prevalence of McArdle disease from gene frequency by analysis of next-generation sequencing … iterative phenotyping for genome-wide analysis of loss-of-function mutations. Am J Hum Genet , 96(6):913-25. 2015. [ …
Educational Resources
Positional cloning is a laboratory technique used to locate the position of a disease-associated gene along the chromosome.
… used to locate the position of a disease-associated gene along the chromosome. … Candidate, Gene, Chromosome, Contig, Deoxyribonucleic Acid (DNA), Gene, Linkage … Positional cloning is a laboratory approach …
News Release
CRGGH researchers Amy Bentley and Charles Rotimi have just completed a large-scale, multi-ancestry genome-wide analysis of gene × smoking interactions on the concentration of serum lipids, including high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), and triglycerides.
… a large-scale, multi-ancestry genome-wide analysis of gene × smoking interactions on the concentration of serum … and triglycerides. … The study was conducted through the Gene-Lifestyle Interactions Working Group of the Cohorts for … ancestry, highlighting the importance of diversity in gene × lifestyle studies. The manuscript describing these …
Educational Resources
An allele is one of two or more versions of a gene.
… Allele … An allele is one of two or more versions of a gene. … Allele, Gene, Homozygous, Autosomal, Mutation, Inherit, Heterozygous, … … An allele is one of two or more versions of a gene. … Educational Resources …
Educational Resources
Deoxyribonucleic acid (abbreviated DNA) is the molecule that carries genetic information for the development and functioning of an organism.
Research Funding
Applications demonstrating excellent grantsmanship, grant mechanisms and research methodologies common to ethical, legal and social implications research.
… Monitoring in Clinical Trials of Germline Gene Editing: Ethical, Legal, and Social Issues Bryan Cwik … Mark Sagoff 2010 Summary Statement Full Application … The grants listed below are examples of well-written applications …