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The Genomics Landscape
In the August 4, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., talks about the establishment of the Global Biodata Coalition (GBC), which aims to move towards more internationally coordinated, sustainable, and streamlined mechanisms that support the biodata ecosystem.
… develop robust and readily available data resources (e.g., databases and knowledgebases). A number of these resources) … For example, as the genomes of the selected set of classic model organisms (e.g., yeast, fruit fly, nematode, and mouse) … resources emerged. This gave rise to the well-known “model organism databases,” such as the Saccharomyces Genome …
Partner with NHGRI
NHGRI's technologies, inventions and discoveries are available for licensing.
… of Technology Transfer Abstract … Mouse Models Mouse Model of Hutchinson-Gilford Progeria Syndrome and Vascular … (NHGRI) and Francis S. Collins, M.D., Ph.D. (NHGRI) Murine Model of Niemann-Pick Disease Type C DHHS Reference No.: … Lead Inventor: William J. Pavan, Ph.D., (NHGRI) Mouse Model of Diamond-Blackfan Anemia DHHS Reference No.: …
News Release
NHGRI researchers, collaborators at the University of California (UC) San Diego, UC Davis and the University of Pittsburgh School of Medicine lay out a new framework for comparing dog-to-human aging, one that uses epigenetics as a biological marker to better understand the aging process.
… between humans and domestic dogs provides an emerging model of aging. … One of the most common misconceptions is … the results obtained with humans. Dogs are a useful model for such comparisons because much of their environment, … translate the age-related physiology experienced by one organism (e.g., humans) to the age at which physiology in a …
The Genomics Landscape
In the April 7, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., highlights the Telomere-to-Telomere (T2T) consortium's publishing of a collection of papers that reported the first truly complete sequence of the human genome.
… about how genomic data may later be shared in databases can sometimes be an afterthought, making it … form and training materials, which could be used as a model by others in point-of-care settings when collecting …
Educational Resources
Bioinformatics is a subdiscipline of biology and computer science concerned with the acquisition, storage, analysis, and dissemination of biological data.
… about those sequences. Scientists and clinicians use databases that organize and index such biological information …
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… researchers, the reasons for using zebrafish as their model organism of choice are as varied as the diseases they study. … For Dr. Brooks' research program, using the zebrafish as a model is both practical and eye-opening."The zebrafish …
Research at NHGRI
The Technology Transfer Office is responsible for transferring NHGRI technologies to the private sector and exchanging research materials with outside groups.
The Genomics Landscape
In 2022, The Genomics Landscape spotlighted genomic data sharing each month in a series of entries. This page contains a collection of each of those entries.
… such as the database of Genotypes and Phenotypes (dbGaP), model organism databases (e.g., Mouse Genome Informatics and Xenbase ), and …
News Release
A genetic mutation that triggers bladder cancer in dogs is identical to a mutation that is implicated in multiple human cancers.
… way that canines may come to our aid-as a powerful animal model for research into human cancer. … A genetic mutation … which is not inherited but rather arises during an organism's lifetime, alters the protein and causes cells to … cancers are similar, and dogs already have served as a model in cancer research. They were central to immune system …
Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… Human Genome Project sequenced the genomes of a number of model organisms that are commonly used as surrogates in … as ENCODE (Encyclopedia of DNA Elements) and modENCODE (model organism Encyclopedia of DNA Elements) have compared and …