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- Genome Technology Program5
- Human Genome Reference Program (HGRP)2
- Impact of Genomic Variation on Function (IGVF) Consortium1
- Encyclopedia of DNA Elements (ENCODE) Project1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)3
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
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- Genomics-Enabled Learning Health Systems (gLHS)1
Educational Resources
Transcription is the process of making an RNA copy of a gene sequence.
… of a gene sequence. … Cell, Cytoplasm, Deoxyribonucleic Acid (DNA), Gene, Gene Expression, Messenger RNA (mRNA), … to the cell cytoplasm (watery interior), where it is used for synthesizing the encoded protein. … Transcription is the …
The Genomics Landscape
In the October 6, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., celebrates the 25th anniversary of the NIH Intramural Sequencing Center (NISC). a well-respected and highly used large-scale DNA sequencing center that exemplifies the evolution of the field of genomics and the ever-increasing abilities to produce prodigious amounts of genomic data.
… Last week, we started a new fiscal year for the federal government. As is often the case, we began … at the NIH funding process as well as provide tips and tools for successful grant writing; this session will take … sequence to public databases weekly, as large-scale DNA sequencing had advanced substantially. At that time, it …
Educational Resources
Cloning is the process of making identical copies of an organism, cell, or DNA sequence.
… isolating and copying a particular DNA segment of interest for further study. … Cloning is the process of making …
Staff
Dr. Randy Chandler is an associate investigator in the Organic Acid Research Section of the Metabolic Medicine Branch in NHGRI.
… Randy Chandler is an associate investigator in the Organic Acid Research (OAR) Section of the Metabolic Medicine Branch … focused on adeno-associated virus (AAV) gene therapy for the treatment of hemophilia A, a genetically inherited … has focused on the efficacy of gene therapy as a treatment for rare genetic disorders, such as methylmalonic acidemia …
Research Funding
A collaborative large-scale genome sequencing effort to identify rare risk and protective variants contributing to multiple common disease phenotypes.
… The Centers for Common Disease Genomics (CCDG) are a collaborative large-scale genome sequencing effort to comprehensively identify rare risk and … studies for common disease. Develop resources, informatics tools, and innovative approaches and technologies for …
News Release
Researchers from NHGRI, Oxford University and other National Institutes of Health centers have developed and tested a new method to predict hospital-acquired infections involving five other important pathogens.
… "But is there a way we can accurately predict your risk for acquiring a hospital-acquired infection just by using … hospital data?" Hospital staff usually test patients for infections when they start showing symptoms, but that … Health Service (NHS) hospitals in Oxfordshire, U.K. for at least 48 hours between 2011 and 2015. The NHS, which …
Educational Resources
A primer is a short, single-stranded DNA sequence used in the polymerase chain reaction (PCR) technique.
… chain reaction (PCR) technique. … Deoxyribonucleic Acid (DNA), Gene Amplification, Hybridization, Polymerase … in a very short timeframe. Primers are also used in DNA sequencing and other experimental processes. … A primer is a …
Clinical Research
This team-based clinical service os provided by NHGRI to Intramural Investigators employing exome/genome sequencing.
… NHGRI to Intramural Investigators employing exome/genome sequencing to accomplish their research goals. The SGFS will annotate de-identified research exome/genome data for the presence of possible actionable secondary variants. … NHGRI to Intramural Investigators employing exome/genome sequencing. ​ … DNA Sequencing, Exam Sequencing, Genome …
Educational Resources
Transgenic means that one or more DNA sequences from another species have been introduced by artificial means.
… by artificial means. … Cell, Cloning, Deoxyribonucleic Acid (DNA), Gene, Germ Line … Transgenic refers to an … Transgenic organisms are generated in the laboratory for research purposes. … Transgenic means that one or more …
The Genomics Landscape
In the October 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes James Thomas as the new director for NIH Intramural Sequencing Center (NISC).
… give this lecture in the Sisters Chapel, a historic site for many reasons including being the place where the late Dr. … Thomas, Ph.D. , as the new director of the NIH Intramural Sequencing Center (NISC) . NISC provides high-throughput DNA … coordinating center will orchestrate sharing the network’s tools and resources with the greater clinical and scientific …